Deafness Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A decreased magnitude of the sensory perception of sound. (Human Phenotype Ontology, HP_0000365)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003638
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Genes

77 genes/proteins associated with the disease Deafness from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MITF microphthalmia-associated transcription factor 2.88009
BDNF brain-derived neurotrophic factor 2.88009
AK2 adenylate kinase 2 2.88009
SLC26A5 solute carrier family 26 (anion exchanger), member 5 2.88009
DFNB59 deafness, autosomal recessive 59 2.88009
ESPN espin 2.88009
SMAD4 SMAD family member 4 2.88009
JAG1 jagged 1 2.88009
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.88009
PAX3 paired box 3 2.88009
GJB3 gap junction protein, beta 3, 31kDa 2.88009
GJB2 gap junction protein, beta 2, 26kDa 2.88009
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2.88009
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.88009
SERAC1 serine active site containing 1 2.88009
PCDH15 protocadherin-related 15 2.88009
RNR1 RNA, ribosomal cluster 1 2.88009
CLDN14 claudin 14 2.88009
OTOF otoferlin 2.88009
VEGFA vascular endothelial growth factor A 1.4313
JUN jun proto-oncogene 1.43076
CAT catalase 1.37817
BAX BCL2-associated X protein 1.36735
LCN2 lipocalin 2 1.36047
VCAM1 vascular cell adhesion molecule 1 1.35906
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.30329
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.29936
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.27936
FASLG Fas ligand (TNF superfamily, member 6) 1.27009
GADD45A growth arrest and DNA-damage-inducible, alpha 1.26732
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.24623
C3 complement component 3 1.22339
FAS Fas cell surface death receptor 1.21727
CP ceruloplasmin (ferroxidase) 1.2046
TP53 tumor protein p53 1.19737
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.19279
DDIT3 DNA-damage-inducible transcript 3 1.18915
CALB1 calbindin 1, 28kDa 1.18554
NOS2 nitric oxide synthase 2, inducible 1.18126
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.18026
C1QA complement component 1, q subcomponent, A chain 1.17497
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.17268
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.16967
TIMP1 TIMP metallopeptidase inhibitor 1 1.16368
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.16001
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.15967
IL6 interleukin 6 1.15661
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.15593
CLU clusterin 1.14507
MCL1 myeloid cell leukemia 1 1.13862
CCNB1 cyclin B1 1.13245
TNF tumor necrosis factor 1.13109
GSTM1 glutathione S-transferase mu 1 1.11707
IL10 interleukin 10 1.1129
GSTP1 glutathione S-transferase pi 1 1.1122
IL1B interleukin 1, beta 1.10069
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.10033
HMOX1 heme oxygenase 1 1.09716
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.09506
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.08337
CD44 CD44 molecule (Indian blood group) 1.08266
FN1 fibronectin 1 1.08161
MPO myeloperoxidase 1.08091
MAPK14 mitogen-activated protein kinase 14 1.08055
MAPK3 mitogen-activated protein kinase 3 1.07625
BIN1 bridging integrator 1 1.07305
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.07234
PPIB peptidylprolyl isomerase B (cyclophilin B) 1.06881
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.06771
COL4A2 collagen, type IV, alpha 2 1.05648
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.04465
CD24 CD24 molecule 1.03382
TAGLN transgelin 1.03382
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.02746
BCL2 B-cell CLL/lymphoma 2 1.02596
CCND1 cyclin D1 1.01587
SOD2 superoxide dismutase 2, mitochondrial 1.01062