DNA Damage Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

216 genes associated with the DNA Damage phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
ALAD aminolevulinate dehydratase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AOX1 aldehyde oxidase 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA5 apolipoprotein A-V
AS3MT arsenite methyltransferase
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BHMT betaine--homocysteine S-methyltransferase
BLM Bloom syndrome, RecQ helicase-like
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CD5 CD5 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPH centromere protein H
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
COMT catechol-O-methyltransferase
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCLRE1C DNA cross-link repair 1C
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUT deoxyuridine triphosphatase
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX3 epoxide hydrolase 3
EPHX4 epoxide hydrolase 4
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
EXO1 exonuclease 1
FAM175A family with sequence similarity 175, member A
FANCG Fanconi anemia, complementation group G
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FPGS folylpolyglutamate synthase
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GHRHR growth hormone releasing hormone receptor
GLRX glutaredoxin (thioltransferase)
GNMT glycine N-methyltransferase
GPX1 glutathione peroxidase 1
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
H2AFX H2A histone family, member X
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFNG interferon, gamma
IGF2R insulin-like growth factor 2 receptor
IL16 interleukin 16
IL19 interleukin 19
INS insulin
IRS1 insulin receptor substrate 1
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLC3 kinesin light chain 3
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KNTC1 kinetochore associated 1
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAT1A methionine adenosyltransferase I, alpha
MBD4 methyl-CpG binding domain protein 4
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MGP matrix Gla protein
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MPG N-methylpurine-DNA glycosylase
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH4 mutS homolog 4
MSH5 mutS homolog 5
MTF1 metal-regulatory transcription factor 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUTYH mutY homolog
MYH1 myosin, heavy chain 1, skeletal muscle, adult
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NDC80 NDC80 kinetochore complex component
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NHEJ1 nonhomologous end-joining factor 1
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
OSGEP O-sialoglycoprotein endopeptidase
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PCNA proliferating cell nuclear antigen
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT8 protein arginine methyltransferase 8
PTEN phosphatase and tensin homolog
RAD18 RAD18 E3 ubiquitin protein ligase
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RECQL4 RecQ protein-like 4
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC1 replication factor C (activator 1) 1, 145kDa
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RIF1 replication timing regulatory factor 1
S100A1 S100 calcium binding protein A1
SETX senataxin
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIRT1 sirtuin 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TDG thymine-DNA glycosylase
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPMT thiopurine S-methyltransferase
TXNRD1 thioredoxin reductase 1
TXNRD2 thioredoxin reductase 2
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UNG uracil-DNA glycosylase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR3 WD repeat domain 3
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZC3H13 zinc finger CCCH-type containing 13
ZNF350 zinc finger protein 350