DMTF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin D binding myb-like transcription factor 1|This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 9988)
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10 interacting proteins for DMTF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATF7IP activating transcription factor 7 interacting protein
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
E2F1 E2F transcription factor 1
MAX MYC associated factor X
MYC v-myc avian myelocytomatosis viral oncogene homolog
SRA1 steroid receptor RNA activator 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TP53 tumor protein p53