DMD Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description dystrophin|The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1756)
External Link http://www.ncbi.nlm.nih.gov/gene/1756
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348 interacting proteins for DMD from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACTA1 actin, alpha 1, skeletal muscle
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ADRA1B adrenoceptor alpha 1B
AGA aspartylglucosaminidase
AHNAK AHNAK nucleoprotein
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMPD3 adenosine monophosphate deaminase 3
ANK2 ankyrin 2, neuronal
ANXA2 annexin A2
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARHGAP32 Rho GTPase activating protein 32
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATM ATM serine/threonine kinase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CADPS Ca++-dependent secretion activator
CADPS2 Ca++-dependent secretion activator 2
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMTA1 calmodulin binding transcription activator 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CATSPER3 cation channel, sperm associated 3
CATSPER4 cation channel, sperm associated 4
CATSPERB catsper channel auxiliary subunit beta
CATSPERD catsper channel auxiliary subunit delta
CATSPERG catsper channel auxiliary subunit gamma
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCP1 CUB domain containing protein 1
CEP44 centrosomal protein 44kDa
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CFL1 cofilin 1 (non-muscle)
CHKB choline kinase beta
CLCA2 chloride channel accessory 2
CLIC2 chloride intracellular channel 2
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CNGA1 cyclic nucleotide gated channel alpha 1
CNGB1 cyclic nucleotide gated channel beta 1
CNOT1 CCR4-NOT transcription complex, subunit 1
CPNE8 copine VIII
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CROT carnitine O-octanoyltransferase
CSN2 casein beta
CST3 cystatin C
CTAGE5 CTAGE family, member 5
CTTN cortactin
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCC DCC netrin 1 receptor
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DERL1 derlin 1
DGKE diacylglycerol kinase, epsilon 64kDa
DGKG diacylglycerol kinase, gamma 90kDa
DGKH diacylglycerol kinase, eta
DGKZ diacylglycerol kinase, zeta
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DNAH3 dynein, axonemal, heavy chain 3
DPY30 dpy-30 homolog (C. elegans)
DRP2 dystrophin related protein 2
DTNA dystrobrevin, alpha
DTNB dystrobrevin, beta
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF4B eukaryotic translation initiation factor 4B
EXOC6 exocyst complex component 6
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM71E2 family with sequence similarity 71, member E2
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FGA fibrinogen alpha chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFAP glial fibrillary acidic protein
GJC2 gap junction protein, gamma 2, 47kDa
GRAP2 GRB2-related adaptor protein 2
GSN gelsolin
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HBA2 hemoglobin, alpha 2
HDLBP high density lipoprotein binding protein
HIST1H1C histone cluster 1, H1c
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
HIST1H4F histone cluster 1, H4f
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HP haptoglobin
HPX hemopexin
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGKC immunoglobulin kappa constant
INA internexin neuronal intermediate filament protein, alpha
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB5 integrin, beta 5
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JARID2 jumonji, AT rich interactive domain 2
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD3 potassium channel tetramerization domain containing 3
KIAA0232 KIAA0232
KIAA1551 KIAA1551
KIF2C kinesin family member 2C
KIF3A kinesin family member 3A
KLK3 kallikrein-related peptidase 3
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT8 keratin 8, type II
KRT9 keratin 9, type I
KTN1 kinectin 1 (kinesin receptor)
LAT linker for activation of T cells
LDB3 LIM domain binding 3
LIMA1 LIM domain and actin binding 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARK2 MAP/microtubule affinity-regulating kinase 2
MCOLN1 mucolipin 1
MCOLN2 mucolipin 2
MCOLN3 mucolipin 3
MPRIP myosin phosphatase Rho interacting protein
MYH9 myosin, heavy chain 9, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYLK3 myosin light chain kinase 3
MYO1C myosin IC
NCL nucleolin
NCOA3 nuclear receptor coactivator 3
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFX1 nuclear transcription factor, X-box binding 1
NLRC4 NLR family, CARD domain containing 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP10 NOP10 ribonucleoprotein
NOS1 nitric oxide synthase 1 (neuronal)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OBSL1 obscurin-like 1
OR2T6 olfactory receptor, family 2, subfamily T, member 6
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PALB2 partner and localizer of BRCA2
PCDH1 protocadherin 1
PCED1B PC-esterase domain containing 1B
PDE4B phosphodiesterase 4B, cAMP-specific
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PF4V1 platelet factor 4 variant 1
PGM5 phosphoglucomutase 5
PHC3 polyhomeotic homolog 3 (Drosophila)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKM pyruvate kinase, muscle
PLA1A phospholipase A1 member A
PLA2G4F phospholipase A2, group IVF
PLAG1 pleiomorphic adenoma gene 1
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POTEKP POTE ankyrin domain family, member K, pseudogene
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRMT5 protein arginine methyltransferase 5
PRSS1 protease, serine, 1 (trypsin 1)
PRSS3 protease, serine, 3
PTCH2 patched 2
PTRF polymerase I and transcript release factor
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RANBP2 RAN binding protein 2
RANBP3 RAN binding protein 3
RBM10 RNA binding motif protein 10
RGS3 regulator of G-protein signaling 3
RLF rearranged L-myc fusion
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL22 ribosomal protein L22
RPL3 ribosomal protein L3
RPL6 ribosomal protein L6
RPL7A ribosomal protein L7a
RPS2 ribosomal protein S2
RPS8 ribosomal protein S8
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SAG S-antigen; retina and pineal gland (arrestin)
SCAF1 SR-related CTD-associated factor 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SCRIB scribbled planar cell polarity protein
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETX senataxin
SF3B2 splicing factor 3b, subunit 2, 145kDa
SGCZ sarcoglycan, zeta
SGOL2 shugoshin-like 2 (S. pombe)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNTA1 syntrophin, alpha 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SNTG1 syntrophin, gamma 1
SNTG2 syntrophin, gamma 2
SNX27 sorting nexin family member 27
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
SPIN1 spindlin 1
SRI sorcin
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STIM1 stromal interaction molecule 1
STK38 serine/threonine kinase 38
STK38L serine/threonine kinase 38 like
STXBP5 syntaxin binding protein 5 (tomosyn)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TMOD3 tropomodulin 3 (ubiquitous)
TMPO thymopoietin
TPCN1 two pore segment channel 1
TPCN2 two pore segment channel 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAPPC11 trafficking protein particle complex 11
TRDN triadin
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D1 TSC22 domain family, member 1
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
TTR transthyretin
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
USP24 ubiquitin specific peptidase 24
UTRN utrophin
VIM vimentin
WDR77 WD repeat domain 77
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZNF232 zinc finger protein 232
ZNF292 zinc finger protein 292
ZRANB2 zinc finger, RAN-binding domain containing 2
ZYX zyxin