Coronary Disease Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
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Genes

82 genes associated with the trait Coronary Disease in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 1.65794
E2F4 E2F transcription factor 4, p107/p130-binding 0.995026
EXOC3L1 exocyst complex component 3-like 1 0.995026
PSRC1 proline/serine-rich coiled-coil 1 0.807263
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.763999
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.711358
SLC12A9 solute carrier family 12, member 9 0.711358
KLHL29 kelch-like family member 29 0.64828
SMAD3 SMAD family member 3 0.609816
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.569403
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.552134
RNF130 ring finger protein 130 0.539181
NLRC5 NLR family, CARD domain containing 5 0.539181
DNM2 dynamin 2 0.50886
GCOM1 GRINL1A complex locus 1 0.50084
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.50084
MIA3 melanoma inhibitory activity family, member 3 0.50084
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.467943
FMN2 formin 2 0.443956
PDGFD platelet derived growth factor D 0.406869
LITAF lipopolysaccharide-induced TNF factor 0.406869
SEZ6L seizure related 6 homolog (mouse)-like 0.378873
LAMC2 laminin, gamma 2 0.378873
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.378873
TNIK TRAF2 and NCK interacting kinase 0.378873
DOCK6 dedicator of cytokinesis 6 0.356676
OPRM1 opioid receptor, mu 1 0.356676
ZFHX3 zinc finger homeobox 3 0.356676
CDH13 cadherin 13 0.33862
DTNB dystrobrevin, beta 0.33862
CSMD1 CUB and Sushi multiple domains 1 0.33862
LPAR3 lysophosphatidic acid receptor 3 0.336814
EDC4 enhancer of mRNA decapping 4 0.310838
PLEKHO2 pleckstrin homology domain containing, family O member 2 0.29992
IGSF5 immunoglobulin superfamily, member 5 0.29992
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.286994
STAB2 stabilin 2 0.286739
LGI2 leucine-rich repeat LGI family, member 2 0.263988
TPRG1 tumor protein p63 regulated 1 0.253763
PDE4A phosphodiesterase 4A, cAMP-specific 0.2435
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.239625
CLMN calmin (calponin-like, transmembrane) 0.232577
ACTN1 actinin, alpha 1 0.225049
KAZN kazrin, periplakin interacting protein 0.218184
RBBP4 retinoblastoma binding protein 4 0.217638
NRXN3 neurexin 3 0.215167
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.208233
ASB2 ankyrin repeat and SOCS box containing 2 0.207789
SIK2 salt-inducible kinase 2 0.196919
RALYL RALY RNA binding protein-like 0.193192
CTR9 CTR9, Paf1/RNA polymerase II complex component 0.189307
PHACTR1 phosphatase and actin regulator 1 0.178057
TFEB transcription factor EB 0.165708
KIF26B kinesin family member 26B 0.16419
MCTP2 multiple C2 domains, transmembrane 2 0.158246
EBF2 early B-cell factor 2 0.157415
CLASP1 cytoplasmic linker associated protein 1 0.148858
ATP8B4 ATPase, class I, type 8B, member 4 0.116901
PTPRE protein tyrosine phosphatase, receptor type, E 0.115372
SAMM50 SAMM50 sorting and assembly machinery component 0.111214
TMEM169 transmembrane protein 169 0.108672
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.107563
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.106907
PDE10A phosphodiesterase 10A 0.103809
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.100794
DENND1A DENN/MADD domain containing 1A 0.093406
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.092962
PARVB parvin, beta 0.086954
PTPRD protein tyrosine phosphatase, receptor type, D 0.08242
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.078402
CAMTA1 calmodulin binding transcription activator 1 0.078287
OR51A7 olfactory receptor, family 51, subfamily A, member 7 0.077701
ZBP1 Z-DNA binding protein 1 0.076917
PCNXL2 pecanex-like 2 (Drosophila) 0.073178
FTO fat mass and obesity associated 0.069385
WWOX WW domain containing oxidoreductase 0.065788
ELF2P2 E74-like factor 2 pseudogene 2 0.06247
RPA1 replication protein A1, 70kDa 0.061721
ZNF580 zinc finger protein 580 0.058714
ZNF581 zinc finger protein 581 0.058714
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.058618
AUTS2 autism susceptibility candidate 2 0.057872