Coronary Disease Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003327
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Genes

350 genes/proteins associated with the disease Coronary Disease from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PON1 paraoxonase 1 2.88009
TMEM57 transmembrane protein 57 2.88009
APOB apolipoprotein B 2.88009
CHDS8 Coronary heart disease, susceptibility to, 8 2.88009
CHDS9 Coronary heart disease, suscpetibility to, 9 2.88009
CHDS1 Coronary heart disease, susceptibility to, 1 2.88009
CHDS2 Coronary heart disease, susceptibility to, 2 2.88009
CHDS3 Coronary heart disease, susceptibility to, 3 2.88009
ACE angiotensin I converting enzyme 2.88009
APOE apolipoprotein E 2.88009
PLAU plasminogen activator, urokinase 2.88009
ESR2 estrogen receptor 2 (ER beta) 2.88009
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.88009
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.88009
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.88009
DNAH11 dynein, axonemal, heavy chain 11 2.88009
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.88009
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.88009
CD36 CD36 molecule (thrombospondin receptor) 2.88009
LDLR low density lipoprotein receptor 2.88009
CHDS4 Coronary heart disease, susceptibility to, 4 2.88009
LPA lipoprotein, Lp(a) 2.88009
CCL2 chemokine (C-C motif) ligand 2 2.37178
TNF tumor necrosis factor 2.36506
NOS3 nitric oxide synthase 3 (endothelial cell) 2.3378
IL6 interleukin 6 2.31358
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.27073
LEP leptin 2.26618
IL1B interleukin 1, beta 2.26325
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.26303
TGFB1 transforming growth factor, beta 1 2.23736
MAPK3 mitogen-activated protein kinase 3 2.18838
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.17866
NOS2 nitric oxide synthase 2, inducible 2.16778
FOS FBJ murine osteosarcoma viral oncogene homolog 2.16371
MAPK1 mitogen-activated protein kinase 1 2.14753
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.12889
HMOX1 heme oxygenase 1 2.1062
CAT catalase 2.06222
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.05918
BAX BCL2-associated X protein 2.05281
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.04463
REN renin 2.03185
VCAM1 vascular cell adhesion molecule 1 2.01979
VEGFA vascular endothelial growth factor A 2.01254
MMP9 matrix metallopeptidase 9 2.0124
APOA1 apolipoprotein A-I 1.99437
PPARA peroxisome proliferator-activated receptor alpha 1.96284
BCL2 B-cell CLL/lymphoma 2 1.95691
SOD2 superoxide dismutase 2, mitochondrial 1.95239
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.93292
EDN1 endothelin 1 1.92234
BDNF brain-derived neurotrophic factor 1.90935
ALB albumin 1.90325
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.89617
PPARG peroxisome proliferator-activated receptor gamma 1.89295
CRP C-reactive protein, pentraxin-related 1.87692
COL1A1 collagen, type I, alpha 1 1.84233
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.83984
MMP2 matrix metallopeptidase 2 1.82761
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.81684
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.81017
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.79484
JUN jun proto-oncogene 1.79292
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.79025
CCND1 cyclin D1 1.7872
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.78397
NPPA natriuretic peptide A 1.77878
TFRC transferrin receptor 1.77316
TP53 tumor protein p53 1.76617
ADRB1 adrenoceptor beta 1 1.76289
ADIPOQ adiponectin, C1Q and collagen domain containing 1.7621
ICAM1 intercellular adhesion molecule 1 1.75321
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.74842
IFNG interferon, gamma 1.74701
FAS Fas cell surface death receptor 1.73898
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.72884
CCL3 chemokine (C-C motif) ligand 3 1.72717
SOCS3 suppressor of cytokine signaling 3 1.72696
NCF1 neutrophil cytosolic factor 1 1.72302
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.71379
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.70823
EGFR epidermal growth factor receptor 1.69103
PCNA proliferating cell nuclear antigen 1.67633
GFAP glial fibrillary acidic protein 1.67483
LPL lipoprotein lipase 1.66749
EGR1 early growth response 1 1.66641
SPP1 secreted phosphoprotein 1 1.65974
IL2 interleukin 2 1.65665
APOC3 apolipoprotein C-III 1.6464
CD40LG CD40 ligand 1.6464
IGF1 insulin-like growth factor 1 (somatomedin C) 1.64123
CXCL8 chemokine (C-X-C motif) ligand 8 1.63966
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.63676
DDIT3 DNA-damage-inducible transcript 3 1.63294
SOD1 superoxide dismutase 1, soluble 1.63027
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.6296
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.62557
ADORA1 adenosine A1 receptor 1.61365
VIM vimentin 1.61271
FGF2 fibroblast growth factor 2 (basic) 1.61131
INS insulin 1.60664
SREBF1 sterol regulatory element binding transcription factor 1 1.60384
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.59614
MAPK8 mitogen-activated protein kinase 8 1.59497
THBS1 thrombospondin 1 1.57971
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.55525
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.54693
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.54669
NOX4 NADPH oxidase 4 1.54523
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.5433
F3 coagulation factor III (thromboplastin, tissue factor) 1.53061
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.52767
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.52464
CLU clusterin 1.52086
CAV1 caveolin 1, caveolae protein, 22kDa 1.51355
SCARB1 scavenger receptor class B, member 1 1.5118
PECAM1 platelet/endothelial cell adhesion molecule 1 1.50675
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.5012
STAR steroidogenic acute regulatory protein 1.50018
IL1A interleukin 1, alpha 1.49736
F2 coagulation factor II (thrombin) 1.48325
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.47608
CYBA cytochrome b-245, alpha polypeptide 1.47452
CYBB cytochrome b-245, beta polypeptide 1.47219
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.46961
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.46781
ANGPTL4 angiopoietin-like 4 1.4575
CDK2 cyclin-dependent kinase 2 1.4522
IL4 interleukin 4 1.44927
FN1 fibronectin 1 1.44681
MMP1 matrix metallopeptidase 1 1.44193
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.43864
JUNB jun B proto-oncogene 1.43864
IL18 interleukin 18 1.43374
CYCS cytochrome c, somatic 1.43239
CCL5 chemokine (C-C motif) ligand 5 1.4202
LEPR leptin receptor 1.41748
MCL1 myeloid cell leukemia 1 1.41559
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.41424
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.40677
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.40486
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.40486
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.40316
DGAT2 diacylglycerol O-acyltransferase 2 1.39757
GAL galanin/GMAP prepropeptide 1.39422
HSPB1 heat shock 27kDa protein 1 1.38946
IL10 interleukin 10 1.37958
GSTP1 glutathione S-transferase pi 1 1.37874
CD40 CD40 molecule, TNF receptor superfamily member 5 1.37676
PENK proenkephalin 1.37246
ADRB2 adrenoceptor beta 2, surface 1.36735
RHOA ras homolog family member A 1.36591
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.36133
NPPB natriuretic peptide B 1.35502
NFE2L2 nuclear factor, erythroid 2-like 2 1.35213
GH1 growth hormone 1 1.35069
IL12B interleukin 12B 1.34983
ATF3 activating transcription factor 3 1.34869
NOX1 NADPH oxidase 1 1.34489
CTGF connective tissue growth factor 1.33791
IL1RN interleukin 1 receptor antagonist 1.33434
APP amyloid beta (A4) precursor protein 1.33287
PLAT plasminogen activator, tissue 1.32993
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.32964
GSN gelsolin 1.32667
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.32132
SGK1 serum/glucocorticoid regulated kinase 1 1.32015
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.31626
FASLG Fas ligand (TNF superfamily, member 6) 1.31596
GSK3B glycogen synthase kinase 3 beta 1.30727
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.30635
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.30543
BCL2L1 BCL2-like 1 1.30117
CPT1A carnitine palmitoyltransferase 1A (liver) 1.30087
CD14 CD14 molecule 1.29719
TIMP1 TIMP metallopeptidase inhibitor 1 1.29657
CD44 CD44 molecule (Indian blood group) 1.29533
IGF1R insulin-like growth factor 1 receptor 1.29348
MMP3 matrix metallopeptidase 3 1.2898
CDK4 cyclin-dependent kinase 4 1.2895
BIRC5 baculoviral IAP repeat containing 5 1.28919
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.28919
TH tyrosine hydroxylase 1.28796
FASN fatty acid synthase 1.28796
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.28241
CXCL10 chemokine (C-X-C motif) ligand 10 1.27936
CCL7 chemokine (C-C motif) ligand 7 1.27875
RETN resistin 1.27845
EDNRA endothelin receptor type A 1.27378
ACTA2 actin, alpha 2, smooth muscle, aorta 1.27255
NOS1 nitric oxide synthase 1 (neuronal) 1.26329
CCNA2 cyclin A2 1.26298
PDGFB platelet-derived growth factor beta polypeptide 1.26236
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.26144
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.26144
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.25807
IGFBP3 insulin-like growth factor binding protein 3 1.25651
CAPN2 calpain 2, (m/II) large subunit 1.25307
GSR glutathione reductase 1.25028
RB1 retinoblastoma 1 1.25028
GPX2 glutathione peroxidase 2 1.24935
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.24687
CALCA calcitonin-related polypeptide alpha 1.24307
GSTM1 glutathione S-transferase mu 1 1.24181
GADD45B growth arrest and DNA-damage-inducible, beta 1.23648
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.23424
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.23011
CREB1 cAMP responsive element binding protein 1 1.22404
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.22177
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.2208
CDK1 cyclin-dependent kinase 1 1.21919
TRAF2 TNF receptor-associated factor 2 1.21695
EDNRB endothelin receptor type B 1.21567
TLR4 toll-like receptor 4 1.21468
TGFB2 transforming growth factor, beta 2 1.2137
ARRB2 arrestin, beta 2 1.21271
ANXA3 annexin A3 1.21239
GJA1 gap junction protein, alpha 1, 43kDa 1.21173
CETP cholesteryl ester transfer protein, plasma 1.20784
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.20196
NEFH neurofilament, heavy polypeptide 1.2013
TSHB thyroid stimulating hormone, beta 1.2013
MPO myeloperoxidase 1.199
KLF4 Kruppel-like factor 4 (gut) 1.19868
CXCR4 chemokine (C-X-C motif) receptor 4 1.19802
SAA1 serum amyloid A1 1.19672
XBP1 X-box binding protein 1 1.19607
IL12A interleukin 12A 1.19412
CDC6 cell division cycle 6 1.19345
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.19014
KRAS Kirsten rat sarcoma viral oncogene homolog 1.19014
GSTM3 glutathione S-transferase mu 3 (brain) 1.18849
MAPT microtubule-associated protein tau 1.18849
ATF4 activating transcription factor 4 1.18652
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.1862
ACTB actin, beta 1.18456
AURKA aurora kinase A 1.18059
HSPA1A heat shock 70kDa protein 1A 1.17629
SREBF2 sterol regulatory element binding transcription factor 2 1.17431
FABP4 fatty acid binding protein 4, adipocyte 1.17366
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.17202
OXT oxytocin/neurophysin I prepropeptide 1.17067
CTSD cathepsin D 1.17
LHB luteinizing hormone beta polypeptide 1.16933
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.16866
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.16833
AGTR1 angiotensin II receptor, type 1 1.16368
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.15763
MAPK9 mitogen-activated protein kinase 9 1.15695
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.15122
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.15089
S100A9 S100 calcium binding protein A9 1.14954
GCLM glutamate-cysteine ligase, modifier subunit 1.14507
AGER advanced glycosylation end product-specific receptor 1.14336
KIF23 kinesin family member 23 1.14302
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.14268
KDR kinase insert domain receptor 1.13724
NQO1 NAD(P)H dehydrogenase, quinone 1 1.13552
SIRT1 sirtuin 1 1.13552
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.13381
BIRC3 baculoviral IAP repeat containing 3 1.13381
CYC1 cytochrome c-1 1.13245
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.12906
NFE2L1 nuclear factor, erythroid 2-like 1 1.12737
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.12254
ANXA2 annexin A2 1.12048
PTK2 protein tyrosine kinase 2 1.12048
BBC3 BCL2 binding component 3 1.12048
MMP7 matrix metallopeptidase 7 1.11809
GPX1 glutathione peroxidase 1 1.1122
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.10388
GATA3 GATA binding protein 3 1.10317
H2AFX H2A histone family, member X 1.10246
G6PD glucose-6-phosphate dehydrogenase 1.10104
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.09927
DDB2 damage-specific DNA binding protein 2, 48kDa 1.09927
CCND3 cyclin D3 1.09786
GSTO1 glutathione S-transferase omega 1 1.09751
ACOX1 acyl-CoA oxidase 1, palmitoyl 1.09576
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.09471
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.09471
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.09297
COL3A1 collagen, type III, alpha 1 1.0919
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.0919
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.0919
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.09154
CHEK2 checkpoint kinase 2 1.08975
CXCL9 chemokine (C-X-C motif) ligand 9 1.08619
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.08619
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.08407
IRF9 interferon regulatory factor 9 1.08161
SELE selectin E 1.08019
AREG amphiregulin 1.07804
SAA3P serum amyloid A3 pseudogene 1.07768
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.07768
RAB31 RAB31, member RAS oncogene family 1.07732
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.07553
TNC tenascin C 1.07518
CXCL5 chemokine (C-X-C motif) ligand 5 1.07518
CD24 CD24 molecule 1.0734
DUSP1 dual specificity phosphatase 1 1.07163
FPR1 formyl peptide receptor 1 1.07093
DCX doublecortin 1.07093
APOC1 apolipoprotein C-I 1.06552
CTSB cathepsin B 1.06515
LCN2 lipocalin 2 1.06515
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.06297
BECN1 beclin 1, autophagy related 1.06225
ACHE acetylcholinesterase (Yt blood group) 1.05793
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.05757
C3 complement component 3 1.05573
MSR1 macrophage scavenger receptor 1 1.05386
ARG2 arginase 2 1.05163
DHCR7 7-dehydrocholesterol reductase 1.04941
TIMP2 TIMP metallopeptidase inhibitor 2 1.04868
CCNB1 cyclin B1 1.04794
LMNA lamin A/C 1.04684
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.04427
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.04427
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.04314
GPX4 glutathione peroxidase 4 1.04201
HSPE1 heat shock 10kDa protein 1 1.04163
EEF2 eukaryotic translation elongation factor 2 1.04163
MVP major vault protein 1.03789
IDI1 isopentenyl-diphosphate delta isomerase 1 1.03678
PRL prolactin 1.03567
PNP purine nucleoside phosphorylase 1.03456
TACC3 transforming, acidic coiled-coil containing protein 3 1.03456
F2R coagulation factor II (thrombin) receptor 1.03456
CP ceruloplasmin (ferroxidase) 1.03419
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.03159
GNAS GNAS complex locus 1.02971
AQP3 aquaporin 3 (Gill blood group) 1.02971
IL13 interleukin 13 1.02933
DRD2 dopamine receptor D2 1.02783
TXNRD1 thioredoxin reductase 1 1.02783
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.02746
SOD3 superoxide dismutase 3, extracellular 1.02485
BMP2 bone morphogenetic protein 2 1.02485
ALAD aminolevulinate dehydratase 1.02485
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.02447
ACACB acetyl-CoA carboxylase beta 1.02373
RPL6 ribosomal protein L6 1.02373
FOXO3 forkhead box O3 1.02262
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.01928
EGR2 early growth response 2 1.01814
MAPK14 mitogen-activated protein kinase 14 1.01739
GADD45G growth arrest and DNA-damage-inducible, gamma 1.01587
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.01512