Coronary Artery Disease Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
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Genes

205 genes associated with the trait Coronary Artery Disease in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.73993
CDKN2B-AS1 CDKN2B antisense RNA 1 1.61823
PHACTR1 phosphatase and actin regulator 1 1.57498
PPAP2B phosphatidic acid phosphatase type 2B 1.36252
ZC3HC1 zinc finger, C3HC-type containing 1 1.31348
ZPR1 ZPR1 zinc finger 1.31165
LIPA lipase A, lysosomal acid, cholesterol esterase 1.10359
MRAS muscle RAS oncogene homolog 1.0818
TCF21 transcription factor 21 1.07287
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 1.07287
KIAA1462 KIAA1462 1.01477
LPA lipoprotein, Lp(a) 0.982475
HHIPL1 HHIP-like 1 0.944178
PSRC1 proline/serine-rich coiled-coil 1 0.907793
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.88185
SMG6 SMG6 nonsense mediated mRNA decay factor 0.866561
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.862644
WDR12 WD repeat domain 12 0.862644
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.862644
COL4A1 collagen, type IV, alpha 1 0.807263
COL4A2 collagen, type IV, alpha 2 0.807263
MIA3 melanoma inhibitory activity family, member 3 0.763999
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.763999
UBE2Z ubiquitin-conjugating enzyme E2Z 0.731179
BCAP29 B-cell receptor-associated protein 29 0.711358
SCN2A sodium channel, voltage gated, type II alpha subunit 0.642907
COL14A1 collagen, type XIV, alpha 1 0.586288
CEP162 centrosomal protein 162kDa 0.567236
ASTN2 astrotactin 2 0.55712
HNF1A HNF1 homeobox A 0.552134
DOCK9 dedicator of cytokinesis 9 0.549357
IL6R interleukin 6 receptor 0.527821
FNDC1 fibronectin type III domain containing 1 0.518003
MRAP2 melanocortin 2 receptor accessory protein 2 0.510057
CHRDL1 chordin-like 1 0.50886
PECAM1 platelet/endothelial cell adhesion molecule 1 0.50084
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.50084
MCTP2 multiple C2 domains, transmembrane 2 0.472374
GSR glutathione reductase 0.467563
BTD biotinidase 0.443956
FRRS1L ferric-chelate reductase 1-like 0.436464
SORBS2 sorbin and SH3 domain containing 2 0.426718
DLC1 DLC1 Rho GTPase activating protein 0.422796
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.422262
ARL3 ADP-ribosylation factor-like 3 0.409485
SEZ6L seizure related 6 homolog (mouse)-like 0.407709
NUP50 nucleoporin 50kDa 0.406836
OLFM4 olfactomedin 4 0.404026
ACSL3 acyl-CoA synthetase long-chain family member 3 0.399096
ZNF264 zinc finger protein 264 0.387942
CDH13 cadherin 13 0.368739
MYO16 myosin XVI 0.358832
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.356676
C10ORF90 chromosome 10 open reading frame 90 0.356596
RBM47 RNA binding motif protein 47 0.354108
SGCZ sarcoglycan, zeta 0.349076
FBN2 fibrillin 2 0.34403
NNT nicotinamide nucleotide transhydrogenase 0.343825
ASIC2 acid sensing (proton gated) ion channel 2 0.33862
SH2B3 SH2B adaptor protein 3 0.33862
BHMT betaine--homocysteine S-methyltransferase 0.333569
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.332501
CAMTA1 calmodulin binding transcription activator 1 0.328014
FN1 fibronectin 1 0.323533
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.323533
EPHA6 EPH receptor A6 0.321793
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.318077
AKAP6 A kinase (PRKA) anchor protein 6 0.316483
PPARD peroxisome proliferator-activated receptor delta 0.306548
RASGRP4 RAS guanyl releasing protein 4 0.304738
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.29992
CENPQ centromere protein Q 0.292598
ZNF783 zinc finger family member 783 0.2864
BCAS4 breast carcinoma amplified sequence 4 0.27893
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.274776
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.272906
ARSB arylsulfatase B 0.271907
ABLIM2 actin binding LIM protein family, member 2 0.269261
PREP prolyl endopeptidase 0.262541
LHFP lipoma HMGIC fusion partner 0.258604
EPHB1 EPH receptor B1 0.25831
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.254094
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.25278
LOC400499 uncharacterized LOC400499 0.251978
VGLL4 vestigial-like family member 4 0.250034
CEP128 centrosomal protein 128kDa 0.249192
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.246614
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.243967
PLXDC2 plexin domain containing 2 0.238991
CHDH choline dehydrogenase 0.23562
KIAA1456 KIAA1456 0.231913
FANK1 fibronectin type III and ankyrin repeat domains 1 0.230907
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.228671
GPR158 G protein-coupled receptor 158 0.223999
ALK anaplastic lymphoma receptor tyrosine kinase 0.223051
LINC01600 long intergenic non-protein coding RNA 1600 0.22032
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.217304
ANO3 anoctamin 3 0.217221
DCHS1 dachsous cadherin-related 1 0.211564
C12ORF50 chromosome 12 open reading frame 50 0.211448
MRPL13 mitochondrial ribosomal protein L13 0.211101
MTBP MDM2 binding protein 0.211101
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.210488
IL16 interleukin 16 0.209842
FAM83B family with sequence similarity 83, member B 0.209427
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.208122
KRT88P keratin 88 pseudogene 0.207229
RIMS1 regulating synaptic membrane exocytosis 1 0.207143
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.20515
IL1RAP interleukin 1 receptor accessory protein 0.200976
PTN pleiotrophin 0.195072
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.193961
PARK2 parkin RBR E3 ubiquitin protein ligase 0.190182
ZNF334 zinc finger protein 334 0.188028
IL4R interleukin 4 receptor 0.186532
PTPRG protein tyrosine phosphatase, receptor type, G 0.185961
GDNF glial cell derived neurotrophic factor 0.18437
GOLGA3 golgin A3 0.184075
C4ORF33 chromosome 4 open reading frame 33 0.179532
ATP10D ATPase, class V, type 10D 0.174519
MUT methylmalonyl CoA mutase 0.174039
CNTN3 contactin 3 (plasmacytoma associated) 0.17211
SHROOM3 shroom family member 3 0.170319
TRIM9 tripartite motif containing 9 0.169567
ZBTB16 zinc finger and BTB domain containing 16 0.168692
RGS7 regulator of G-protein signaling 7 0.168692
BARD1 BRCA1 associated RING domain 1 0.167633
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.163792
DEF6 differentially expressed in FDCP 6 homolog (mouse) 0.163792
LY86 lymphocyte antigen 86 0.162818
NRXN3 neurexin 3 0.161288
AURKC aurora kinase C 0.16105
FAM187B family with sequence similarity 187, member B 0.159754
C9ORF72 chromosome 9 open reading frame 72 0.155247
DMGDH dimethylglycine dehydrogenase 0.15508
KIAA0825 KIAA0825 0.154169
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.153293
SVOP SV2 related protein homolog (rat) 0.148655
MEGF11 multiple EGF-like-domains 11 0.147188
ACOT11 acyl-CoA thioesterase 11 0.143572
LRRC74A leucine rich repeat containing 74A 0.14054
FYN FYN proto-oncogene, Src family tyrosine kinase 0.139507
ACO1 aconitase 1, soluble 0.139428
CELF2 CUGBP, Elav-like family member 2 0.136013
SH3RF3 SH3 domain containing ring finger 3 0.135963
LRRC20 leucine rich repeat containing 20 0.132767
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.131089
TOR1A torsin family 1, member A (torsin A) 0.128803
SMYD4 SET and MYND domain containing 4 0.125498
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.125
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.117847
BCAS1 breast carcinoma amplified sequence 1 0.117782
MACROD2 MACRO domain containing 2 0.114994
CNRIP1 cannabinoid receptor interacting protein 1 0.113952
TRBV30 T cell receptor beta variable 30 (gene/pseudogene) 0.113807
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.112552
CCDC60 coiled-coil domain containing 60 0.109183
C20ORF27 chromosome 20 open reading frame 27 0.108496
STK35 serine/threonine kinase 35 0.106734
ABI3BP ABI family, member 3 (NESH) binding protein 0.1066
PCCA propionyl CoA carboxylase, alpha polypeptide 0.103512
ADGRV1 adhesion G protein-coupled receptor V1 0.103493
SUGCT succinyl-CoA:glutarate-CoA transferase 0.10305
GPC5 glypican 5 0.100328
DIRAS2 DIRAS family, GTP-binding RAS-like 2 0.099935
CORIN corin, serine peptidase 0.099793
DENND1B DENN/MADD domain containing 1B 0.097182
UST uronyl-2-sulfotransferase 0.095658
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.09515
C5ORF34 chromosome 5 open reading frame 34 0.0951
KIRREL kin of IRRE like (Drosophila) 0.094544
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.094377
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.09376
ARHGAP42 Rho GTPase activating protein 42 0.092931
MKL1 megakaryoblastic leukemia (translocation) 1 0.09115
HDAC9 histone deacetylase 9 0.08942
EBF1 early B-cell factor 1 0.089318
ZNF813 zinc finger protein 813 0.086134
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.08549
BCCIP BRCA2 and CDKN1A interacting protein 0.084201
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 0.084201
PEBP4 phosphatidylethanolamine-binding protein 4 0.079733
CCDC68 coiled-coil domain containing 68 0.076841
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.076177
C10ORF11 chromosome 10 open reading frame 11 0.075618
TOR1B torsin family 1, member B (torsin B) 0.07208
THAP2 THAP domain containing, apoptosis associated protein 2 0.071512
ZFC3H1 zinc finger, C3H1-type containing 0.071512
TMEM245 transmembrane protein 245 0.069053
CARD10 caspase recruitment domain family, member 10 0.068358
FGD6 FYVE, RhoGEF and PH domain containing 6 0.06756
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.06716
HACD4 3-hydroxyacyl-CoA dehydratase 4 0.06688
WDR49 WD repeat domain 49 0.066645
SH2D4A SH2 domain containing 4A 0.066484
FHIT fragile histidine triad 0.06561
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 0.062928
FNDC3B fibronectin type III domain containing 3B 0.061554
TCTN3 tectonic family member 3 0.061056
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.059972
WWOX WW domain containing oxidoreductase 0.059972
DCAF5 DDB1 and CUL4 associated factor 5 0.05951
TMEM233 transmembrane protein 233 0.059477
MEOX2 mesenchyme homeobox 2 0.058117
FGFR1 fibroblast growth factor receptor 1 0.058053