Conduct Disorder Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated. (Human Disease Ontology, DOID_12995)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D019955
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Genes

191 genes/proteins associated with the disease Conduct Disorder from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BDNF brain-derived neurotrophic factor 2.10207
FOS FBJ murine osteosarcoma viral oncogene homolog 2.00898
PRL prolactin 1.97464
DRD2 dopamine receptor D2 1.96964
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.91765
EGR1 early growth response 1 1.88605
TH tyrosine hydroxylase 1.81429
CAT catalase 1.80623
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.77762
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.7566
MAPK1 mitogen-activated protein kinase 1 1.71399
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.69972
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.67526
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.65599
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.65023
MAPK8 mitogen-activated protein kinase 8 1.64933
FNDC4 fibronectin type III domain containing 4 1.6381
SOD1 superoxide dismutase 1, soluble 1.62036
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.61782
GSTP1 glutathione S-transferase pi 1 1.61413
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.60967
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.60781
DUSP1 dual specificity phosphatase 1 1.60711
NPY neuropeptide Y 1.59264
NUPR1 nuclear protein, transcriptional regulator, 1 1.58255
INHBE inhibin, beta E 1.5745
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.57426
TNF tumor necrosis factor 1.55921
CDK5 cyclin-dependent kinase 5 1.5501
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.54645
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.54451
JUN jun proto-oncogene 1.54062
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.53086
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.52338
TAGLN transgelin 1.52136
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.51632
C10ORF10 chromosome 10 open reading frame 10 1.51632
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.51305
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.50549
HOMER1 homer scaffolding protein 1 1.49508
MAOB monoamine oxidase B 1.48993
FAS Fas cell surface death receptor 1.47813
FABP1 fatty acid binding protein 1, liver 1.47711
CRH corticotropin releasing hormone 1.47244
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.46198
DRD1 dopamine receptor D1 1.45883
MAOA monoamine oxidase A 1.45723
GAL galanin/GMAP prepropeptide 1.45273
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.45036
ARC activity-regulated cytoskeleton-associated protein 1.4479
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.44139
MAPK3 mitogen-activated protein kinase 3 1.43892
CREB1 cAMP responsive element binding protein 1 1.43184
IL6 interleukin 6 1.4275
BAX BCL2-associated X protein 1.41748
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.41613
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.41202
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.40373
LDLR low density lipoprotein receptor 1.39813
INHA inhibin, alpha 1.3917
JUNB jun B proto-oncogene 1.38043
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.37761
BCL2 B-cell CLL/lymphoma 2 1.37275
GSTM1 glutathione S-transferase mu 1 1.37018
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.36562
DCLK1 doublecortin-like kinase 1 1.35792
OGG1 8-oxoguanine DNA glycosylase 1.35012
CAMK2B calcium/calmodulin-dependent protein kinase II beta 1.34869
PENK proenkephalin 1.34694
TAC1 tachykinin, precursor 1 1.34547
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.34518
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.33081
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.33081
CCND3 cyclin D3 1.32458
EGR3 early growth response 3 1.32015
CCND1 cyclin D1 1.31178
SOD2 superoxide dismutase 2, mitochondrial 1.30758
CTSK cathepsin K 1.30451
ENO1 enolase 1, (alpha) 1.3036
NGFR nerve growth factor receptor 1.2895
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.2895
GRIK2 glutamate receptor, ionotropic, kainate 2 1.2895
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.28241
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.27689
BCL2L1 BCL2-like 1 1.27595
GFAP glial fibrillary acidic protein 1.27224
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.27132
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.26886
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.26483
GAP43 growth associated protein 43 1.26452
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.26236
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.2599
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.25745
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.25713
CXCL8 chemokine (C-X-C motif) ligand 8 1.25059
GNA12 guanine nucleotide binding protein (G protein) alpha 12 1.24874
FSHB follicle stimulating hormone, beta polypeptide 1.2456
MAP2K1 mitogen-activated protein kinase kinase 1 1.24433
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.23616
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.23169
GJA1 gap junction protein, alpha 1, 43kDa 1.22853
FGF2 fibroblast growth factor 2 (basic) 1.22501
MBP myelin basic protein 1.22469
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.22469
GSK3A glycogen synthase kinase 3 alpha 1.22209
IL1A interleukin 1, alpha 1.22048
SREBF1 sterol regulatory element binding transcription factor 1 1.21951
HPN hepsin 1.21855
ADORA1 adenosine A1 receptor 1.21011
EGR2 early growth response 2 1.21011
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.20687
TP53 tumor protein p53 1.20427
HMOX1 heme oxygenase 1 1.20361
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.19312
PRKCE protein kinase C, epsilon 1.19146
DRD4 dopamine receptor D4 1.19113
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.19113
SNAP25 synaptosomal-associated protein, 25kDa 1.18489
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.18359
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.17993
DUSP6 dual specificity phosphatase 6 1.1786
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.17268
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.17
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.16666
RELN reelin 1.16137
OPRM1 opioid receptor, mu 1 1.1607
IFNG interferon, gamma 1.15865
SREBF2 sterol regulatory element binding transcription factor 2 1.15593
CNR1 cannabinoid receptor 1 (brain) 1.15357
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.15189
GSK3B glycogen synthase kinase 3 beta 1.14302
ACTB actin, beta 1.13929
PIR pirin (iron-binding nuclear protein) 1.13177
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.13075
FKBP4 FK506 binding protein 4, 59kDa 1.1294
RGS4 regulator of G-protein signaling 4 1.12737
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.12703
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.12495
LITAF lipopolysaccharide-induced TNF factor 1.12461
MAP1A microtubule-associated protein 1A 1.11945
NFE2L2 nuclear factor, erythroid 2-like 2 1.11877
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 1.11775
HPCAL4 hippocalcin like 4 1.10838
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.10424
EZR ezrin 1.10424
GRIK5 glutamate receptor, ionotropic, kainate 5 1.09857
PHGDH phosphoglycerate dehydrogenase 1.09751
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.09401
HSPA8 heat shock 70kDa protein 8 1.08655
CXCL5 chemokine (C-X-C motif) ligand 5 1.08091
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.08091
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.07911
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.07128
NOS2 nitric oxide synthase 2, inducible 1.06987
DRD3 dopamine receptor D3 1.06844
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.06552
ARG2 arginase 2 1.0637
VEGFA vascular endothelial growth factor A 1.0637
ADIPOQ adiponectin, C1Q and collagen domain containing 1.05936
PDE4A phosphodiesterase 4A, cAMP-specific 1.05828
EEF2 eukaryotic translation elongation factor 2 1.05648
PGK1 phosphoglycerate kinase 1 1.05461
CHGA chromogranin A 1.05423
SYN2 synapsin II 1.05386
CDK4 cyclin-dependent kinase 4 1.05126
NRG1 neuregulin 1 1.05089
OXT oxytocin/neurophysin I prepropeptide 1.05089
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 1.05052
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 1.05015
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.04904
HSPA1A heat shock 70kDa protein 1A 1.04904
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.04757
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.04647
ARRB1 arrestin, beta 1 1.04163
GSR glutathione reductase 1.03456
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.03122
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.02522
CALR calreticulin 1.02485
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.02373
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.02336
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.02225
RGS2 regulator of G-protein signaling 2 1.02225
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.02188
NPY1R neuropeptide Y receptor Y1 1.0204
ACSL6 acyl-CoA synthetase long-chain family member 6 1.02003
ATF3 activating transcription factor 3 1.01928
AANAT aralkylamine N-acetyltransferase 1.0189
PRKCB protein kinase C, beta 1.0189
CD177 CD177 molecule 1.01739
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.01549
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.01512