Colorectal Neoplasms, Hereditary Nonpolyposis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

97 genes associated with the Colorectal Neoplasms, Hereditary Nonpolyposis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ADAMTSL3 ADAMTS-like 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
APC adenomatous polyposis coli
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CFAP52 cilia and flagella associated protein 52
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
COLCA2 colorectal cancer associated 2
COMT catechol-O-methyltransferase
CSMD3 CUB and Sushi multiple domains 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F2 E2F transcription factor 2
EDRF1 erythroid differentiation regulatory factor 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
EPHB6 EPH receptor B6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXO1 exonuclease 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GREM1 gremlin 1, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HFE hemochromatosis
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
KAT2A K(lysine) acetyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA1 laminin, alpha 1
LIG4 ligase IV, DNA, ATP-dependent
MAP2K7 mitogen-activated protein kinase kinase 7
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMRN1 multimerin 1
MRC1 mannose receptor, C type 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUTYH mutY homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
OR51E1 olfactory receptor, family 51, subfamily E, member 1
PCNA proliferating cell nuclear antigen
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLIN4 perilipin 4
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PTEN phosphatase and tensin homolog
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHPN2 rhophilin, Rho GTPase binding protein 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
STK11 serine/threonine kinase 11
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNF tumor necrosis factor
TNN tenascin N
TP53 tumor protein p53
TP73 tumor protein p73
UNC5C unc-5 homolog C (C. elegans)
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3