Colonic Polyps Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon (Mammalian Phenotype Ontology, MP_0003269)
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Genes

53 genes associated with the Colonic Polyps phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APC adenomatous polyposis coli
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EGFR epidermal growth factor receptor
ENG endoglin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
F5 coagulation factor V (proaccelerin, labile factor)
GH1 growth hormone 1
HDAC3 histone deacetylase 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL6 interleukin 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LTA lymphotoxin alpha
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MSH6 mutS homolog 6
MUTYH mutY homolog
MYNN myoneurin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OGG1 8-oxoguanine DNA glycosylase
PARK2 parkin RBR E3 ubiquitin protein ligase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNKP polynucleotide kinase 3'-phosphatase
PPARG peroxisome proliferator-activated receptor gamma
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
STK11 serine/threonine kinase 11
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TRPM7 transient receptor potential cation channel, subfamily M, member 7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1