Cognition Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

315 genes associated with the Cognition Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACT actin-like protein (ACT) gene
ADD1 adducin 1 (alpha)
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASTN2 astrotactin 2
BACE1 beta-site APP-cleaving enzyme 1
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCO1 beta-carotene oxygenase 1
BDNF brain-derived neurotrophic factor
BIN1 bridging integrator 1
BMP6 bone morphogenetic protein 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
C3 complement component 3
C5 complement component 5
C9ORF72 chromosome 9 open reading frame 72
CADPS2 Ca++-dependent secretion activator 2
CALHM1 calcium homeostasis modulator 1
CAMTA1 calmodulin binding transcription activator 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCDC134 coiled-coil domain containing 134
CCL2 chemokine (C-C motif) ligand 2
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD2AP CD2-associated protein
CD33 CD33 molecule
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHAT choline O-acetyltransferase
CHMP2B charged multivesicular body protein 2B
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CNTN5 contactin 5
COMT catechol-O-methyltransferase
CPLX2 complexin 2
CPOX coproporphyrinogen oxidase
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CSMD2 CUB and Sushi multiple domains 2
CST3 cystatin C
CTSD cathepsin D
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DISC1 disrupted in schizophrenia 1
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DMD dystrophin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DTNBP1 dystrobrevin binding protein 1
EHF ets homologous factor
EPC2 enhancer of polycomb homolog 2 (Drosophila)
EPHA1 EPH receptor A1
EPHA4 EPH receptor A4
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FADS2 fatty acid desaturase 2
FAM46A family with sequence similarity 46, member A
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FAS Fas cell surface death receptor
FBF1 Fas (TNFRSF6) binding factor 1
FBXW8 F-box and WD repeat domain containing 8
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FHL5 four and a half LIM domains 5
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOXQ1 forkhead box Q1
FRDA2 Friedreich ataxia 2
FTO fat mass and obesity associated
FUS FUS RNA binding protein
FUT2 fucosyltransferase 2 (secretor status included)
GBA glucosidase, beta, acid
GC group-specific component (vitamin D binding protein)
GHRL ghrelin/obestatin prepropeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPC6 glypican 6
GPR137B G protein-coupled receptor 137B
GRAMD3 GRAM domain containing 3
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM3 glutamate receptor, metabotropic 3
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HDAC1 histone deacetylase 1
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPS4 Hermansky-Pudlak syndrome 4
HRAS Harvey rat sarcoma viral oncogene homolog
HRK harakiri, BCL2 interacting protein
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IFNG interferon, gamma
IL10 interleukin 10
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLC1 kinesin light chain 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIPC lipase, hepatic
LMNA lamin A/C
LPL lipoprotein lipase
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LRP1 low density lipoprotein receptor-related protein 1
LRP2 low density lipoprotein receptor-related protein 2
LRRK2 leucine-rich repeat kinase 2
LRRTM3 leucine rich repeat transmembrane neuronal 3
LTA lymphotoxin alpha
LYRM4 LYR motif containing 4
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAOA monoamine oxidase A
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPT microtubule-associated protein tau
MAT1A methionine adenosyltransferase I, alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MECP2 methyl CpG binding protein 2
MET MET proto-oncogene, receptor tyrosine kinase
MICB MHC class I polypeptide-related sequence B
MIR137 microRNA 137
MIR146A microRNA 146a
MMP3 matrix metallopeptidase 3
MOK MOK protein kinase
MPO myeloperoxidase
MRPL38 mitochondrial ribosomal protein L38
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSRB3 methionine sulfoxide reductase B3
MT-TG tRNA
MT-TL2 tRNA
MT-TQ tRNA
MT-TR tRNA
MT-TS2 tRNA
MT-TT tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MX1 MX dynamin-like GTPase 1
MYH13 myosin, heavy chain 13, skeletal muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEUROG1 neurogenin 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPPA natriuretic peptide A
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
NRG3 neuregulin 3
NT5DC1 5'-nucleotidase domain containing 1
NXPH1 neurexophilin 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARK2 parkin RBR E3 ubiquitin protein ligase
PCDH11X protocadherin 11 X-linked
PDE4D phosphodiesterase 4D, cAMP-specific
PDE7A phosphodiesterase 7A
PDYN prodynorphin
PER3 period circadian clock 3
PHF2 PHD finger protein 2
PICALM phosphatidylinositol binding clathrin assembly protein
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKNOX2 PBX/knotted 1 homeobox 2
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRNP prion protein
PSEN1 presenilin 1
PSEN2 presenilin 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRO protein tyrosine phosphatase, receptor type, O
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELN reelin
RGS4 regulator of G-protein signaling 4
S100B S100 calcium binding protein B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT1 sterol O-acyltransferase 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOS1 son of sevenless homolog 1 (Drosophila)
SPON1 spondin 1, extracellular matrix protein
SREBF2 sterol regulatory element binding transcription factor 2
STAC SH3 and cysteine rich domain
STH saitohin
STS steroid sulfatase (microsomal), isozyme S
SULT4A1 sulfotransferase family 4A, member 1
SUMO1P1 SUMO1 pseudogene 1
SYNGAP1 synaptic Ras GTPase activating protein 1
TCF4 transcription factor 4
TF transferrin
TMEM106B transmembrane protein 106B
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TP53 tumor protein p53
TP63 tumor protein p63
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TREM2 triggering receptor expressed on myeloid cells 2
TRIM47 tripartite motif containing 47
TRIM65 tripartite motif containing 65
TRNE
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSNAX translin-associated factor X
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBQLN1 ubiquilin 1
UFD1L ubiquitin fusion degradation 1 like (yeast)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WBP2 WW domain binding protein 2
WIF1 WNT inhibitory factor 1
WRN Werner syndrome, RecQ helicase-like
WWC1 WW and C2 domain containing 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC8 zinc finger, DHHC-type containing 8
ZNF608 zinc finger protein 608
ZNF804A zinc finger protein 804A