Clozapine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. (Chemical Entities of Biological Interest Ontology, CHEBI_3766)
External Link http://ctdbase.org/detail.go?type=chem&acc=D003024
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Genes

125 genes/proteins interacting with the chemical Clozapine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADCY5 adenylate cyclase 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOA5 apolipoprotein A-V
APOD apolipoprotein D
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
CCK cholecystokinin
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRM1 cholinergic receptor, muscarinic 1
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CPT2 carnitine palmitoyltransferase 2
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DISC1 disrupted in schizophrenia 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DTNBP1 dystrobrevin binding protein 1
DVL3 dishevelled segment polarity protein 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK1 ELK1, member of ETS oncogene family
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GFAP glial fibrillary acidic protein
GIP gastric inhibitory polypeptide
GJA1 gap junction protein, alpha 1, 43kDa
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HRH1 histamine receptor H1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL2RA interleukin 2 receptor, alpha
IL5 interleukin 5
INS insulin
JAK2 Janus kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KMT2A lysine (K)-specific methyltransferase 2A
LEP leptin
LPL lipoprotein lipase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
OXT oxytocin/neurophysin I prepropeptide
PDE10A phosphodiesterase 10A
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRL prolactin
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RGS7 regulator of G-protein signaling 7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SOD1 superoxide dismutase 1, soluble
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SST somatostatin
TH tyrosine hydroxylase
TNF tumor necrosis factor
TTR transthyretin
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4