Choroidal Neovascularization Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera (Mammalian Phenotype Ontology, MP_0005546)
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Genes

68 genes associated with the Choroidal Neovascularization phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
APOE apolipoprotein E
ARMS2 age-related maculopathy susceptibility 2
BFAR bifunctional apoptosis regulator
C2 complement component 2
C3 complement component 3
CCR3 chemokine (C-C motif) receptor 3
CD36 CD36 molecule (thrombospondin receptor)
CETP cholesteryl ester transfer protein, plasma
CFB complement factor B
CFH complement factor H
CFHR4 complement factor H-related 4
CFHR5 complement factor H-related 5
CFI complement factor I
COL1A2 collagen, type I, alpha 2
COL8A1 collagen, type VIII, alpha 1
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELN elastin
ELOVL4 ELOVL fatty acid elongase 4
ERCC6 excision repair cross-complementation group 6
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FADS1 fatty acid desaturase 1
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMCN1 hemicentin 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTRA1 HtrA serine peptidase 1
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL6 interleukin 6
LIPC lipase, hepatic
LOC389641 uncharacterized LOC389641
LPL lipoprotein lipase
MFGE8 milk fat globule-EGF factor 8 protein
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NELFE negative elongation factor complex member E
NOA1 nitric oxide associated 1
NPHP1 nephronophthisis 1 (juvenile)
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PON1 paraoxonase 1
REST RE1-silencing transcription factor
RORA RAR-related orphan receptor A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SOD2 superoxide dismutase 2, mitochondrial
TIMP3 TIMP metallopeptidase inhibitor 3
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor