Ceramide signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering. The pathway plays important roles in apoptosis. (Pathway Ontology, PW_0000961)
External Link http://public.ndexbio.org/#/network/d3747df2-6190-11e5-8ac5-06603eb7f303
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Genes

44 proteins participating in the Ceramide signaling pathway pathway from the PID Pathways dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BAD BCL2-associated agonist of cell death
BAG4 BCL2-associated athanogene 4
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
CASP8 caspase 8, apoptosis-related cysteine peptidase
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTSD cathepsin D
CYCS cytochrome c, somatic
EGF epidermal growth factor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FADD Fas (TNFRSF6)-associated via death domain
KSR1 kinase suppressor of ras 1
MADD MAP-kinase activating death domain
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAWR PRKC, apoptosis, WT1, regulator
PDGFA platelet-derived growth factor alpha polypeptide
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SPHK2 sphingosine kinase 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2