CP-690334-01-4558 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the CP-690334-01-4558 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADARB1 adenosine deaminase, RNA-specific, B1
AMT aminomethyltransferase
ANGPT4 angiopoietin 4
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BTG2 BTG family, member 2
C22ORF46 chromosome 22 open reading frame 46
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CCDC102B coiled-coil domain containing 102B
CCDC40 coiled-coil domain containing 40
CD58 CD58 molecule
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRYGD crystallin, gamma D
CTGF connective tissue growth factor
CTNND2 catenin (cadherin-associated protein), delta 2
CYB5R2 cytochrome b5 reductase 2
CYTH1 cytohesin 1
DCHS2 dachsous cadherin-related 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DOK4 docking protein 4
DST dystonin
DTNA dystrobrevin, alpha
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERO1LB ERO1-like beta (S. cerevisiae)
FAM63B family with sequence similarity 63, member B
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGFR2 fibroblast growth factor receptor 2
FH fumarate hydratase
FYB FYN binding protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLI2 GLI family zinc finger 2
GOLGA6A golgin A6 family, member A
HIST1H2BM histone cluster 1, H2bm
HIST1H3B histone cluster 1, H3b
HPCA hippocalcin
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNA14 interferon, alpha 14
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KANSL3 KAT8 regulatory NSL complex subunit 3
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KERA keratocan
KIAA0040 KIAA0040
KIF5C kinesin family member 5C
KLHL29 kelch-like family member 29
KRTAP1-3 keratin associated protein 1-3
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOXL3 lysyl oxidase-like 3
MAP2 microtubule-associated protein 2
METTL7A methyltransferase like 7A
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NKTR natural killer cell triggering receptor
NRG2 neuregulin 2
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PCDH12 protocadherin 12
PDLIM3 PDZ and LIM domain 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLVAP plasmalemma vesicle associated protein
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTCRA pre T-cell antigen receptor alpha
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARA retinoic acid receptor, alpha
RBM12B RNA binding motif protein 12B
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RUNX1 runt-related transcription factor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEC14L4 SEC14-like 4 (S. cerevisiae)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT4 sirtuin 4
SLC17A4 solute carrier family 17, member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOX10 SRY (sex determining region Y)-box 10
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
TDRD1 tudor domain containing 1
THEMIS2 thymocyte selection associated family member 2
TMEM212 transmembrane protein 212
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TTC12 tetratricopeptide repeat domain 12
TTN titin
TXNRD2 thioredoxin reductase 2
VLDLR very low density lipoprotein receptor
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AEN apoptosis enhancing nuclease
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP10 Rho GTPase activating protein 10
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARL14 ADP-ribosylation factor-like 14
ARL15 ADP-ribosylation factor-like 15
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAT1 alpha tubulin acetyltransferase 1
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C22ORF29 chromosome 22 open reading frame 29
CCDC68 coiled-coil domain containing 68
CEMIP cell migration inducing protein, hyaluronan binding
CHMP6 charged multivesicular body protein 6
CLCF1 cardiotrophin-like cytokine factor 1
CLIC3 chloride intracellular channel 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DNAH7 dynein, axonemal, heavy chain 7
DUSP8 dual specificity phosphatase 8
EFNA3 ephrin-A3
EFNB1 ephrin-B1
EHF ets homologous factor
EVPL envoplakin
FAM131B family with sequence similarity 131, member B
FAM160B2 family with sequence similarity 160, member B2
FAM186A family with sequence similarity 186, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO4 flavin containing monooxygenase 4
FPGS folylpolyglutamate synthase
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HOOK1 hook microtubule-tethering protein 1
INCENP inner centromere protein antigens 135/155kDa
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0895 KIAA0895
KLF3 Kruppel-like factor 3 (basic)
KRT6A keratin 6A, type II
KRT8P12 keratin 8 pseudogene 12
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAGEF1 melanoma antigen family F1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MT1M metallothionein 1M
NAT6 N-acetyltransferase 6 (GCN5-related)
NDP Norrie disease (pseudoglioma)
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NME6 NME/NM23 nucleoside diphosphate kinase 6
NOD1 nucleotide-binding oligomerization domain containing 1
NTSR1 neurotensin receptor 1 (high affinity)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP3 poly (ADP-ribose) polymerase family, member 3
PGPEP1 pyroglutamyl-peptidase I
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGFR prostaglandin F receptor (FP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
QTRT1 queuine tRNA-ribosyltransferase 1
RHOBTB2 Rho-related BTB domain containing 2
RUSC2 RUN and SH3 domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD8 SET domain containing (lysine methyltransferase) 8
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMYD5 SMYD family member 5
SPAG4 sperm associated antigen 4
SPEG SPEG complex locus
SYT17 synaptotagmin XVII
THBS3 thrombospondin 3
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
UBL4A ubiquitin-like 4A
USP20 ubiquitin specific peptidase 20
WDR19 WD repeat domain 19
ZNF248 zinc finger protein 248
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768