CP-690334-01-3826 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the CP-690334-01-3826 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACRV1 acrosomal vesicle protein 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACTN2 actinin, alpha 2
ADORA1 adenosine A1 receptor
ATP11A ATPase, class VI, type 11A
BATF basic leucine zipper transcription factor, ATF-like
BTN3A2 butyrophilin, subfamily 3, member A2
C7ORF69 chromosome 7 open reading frame 69
C8ORF44 chromosome 8 open reading frame 44
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC134 coiled-coil domain containing 134
CD93 CD93 molecule
CES3 carboxylesterase 3
CLDN9 claudin 9
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREBBP CREB binding protein
CST4 cystatin S
CTSE cathepsin E
CTSZ cathepsin Z
CXCR6 chemokine (C-X-C motif) receptor 6
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCLK2 doublecortin-like kinase 2
DEPDC5 DEP domain containing 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DKFZP434L187 uncharacterized LOC26082
ELN elastin
ESR1 estrogen receptor 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM163A family with sequence similarity 163, member A
FAM46C family with sequence similarity 46, member C
FGF22 fibroblast growth factor 22
FPR2 formyl peptide receptor 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GFI1 growth factor independent 1 transcription repressor
GP6 glycoprotein VI (platelet)
GPR137 G protein-coupled receptor 137
GPR85 G protein-coupled receptor 85
GSTTP1 glutathione S-transferase theta pseudogene 1
HAL histidine ammonia-lyase
HFE hemochromatosis
HIF3A hypoxia inducible factor 3, alpha subunit
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ING2 inhibitor of growth family, member 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUND jun D proto-oncogene
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLRF1 killer cell lectin-like receptor subfamily F, member 1
KRT19P2 keratin 19 pseudogene 2
LINC00115 long intergenic non-protein coding RNA 115
LINC00216 long intergenic non-protein coding RNA 216
LMOD1 leiomodin 1 (smooth muscle)
LPL lipoprotein lipase
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K6 mitogen-activated protein kinase kinase 6
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED25 mediator complex subunit 25
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP24 matrix metallopeptidase 24 (membrane-inserted)
NDRG2 NDRG family member 2
NPY2R neuropeptide Y receptor Y2
OMG oligodendrocyte myelin glycoprotein
PCDHA5 protocadherin alpha 5
PDE2A phosphodiesterase 2A, cGMP-stimulated
PIGR polymeric immunoglobulin receptor
PKNOX2 PBX/knotted 1 homeobox 2
POLL polymerase (DNA directed), lambda
POU2F2 POU class 2 homeobox 2
RAB26 RAB26, member RAS oncogene family
RAB40A RAB40A, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RFXAP regulatory factor X-associated protein
RGS12 regulator of G-protein signaling 12
RPL10 ribosomal protein L10
RUNX1 runt-related transcription factor 1
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SHOX2 short stature homeobox 2
SLAMF8 SLAM family member 8
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STOML1 stomatin (EPB72)-like 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TNXB tenascin XB
TOX thymocyte selection-associated high mobility group box
TP63 tumor protein p63
TP73-AS1 TP73 antisense RNA 1
TTYH1 tweety family member 1
TUBA3C tubulin, alpha 3c
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZNF550 zinc finger protein 550
ZNF667 zinc finger protein 667
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABI3BP ABI family, member 3 (NESH) binding protein
AKAP5 A kinase (PRKA) anchor protein 5
ANKH ANKH inorganic pyrophosphate transport regulator
ANXA10 annexin A10
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOL6 apolipoprotein L, 6
ARC activity-regulated cytoskeleton-associated protein
ARMC4 armadillo repeat containing 4
ART1 ADP-ribosyltransferase 1
C14ORF93 chromosome 14 open reading frame 93
CD82 CD82 molecule
CINP cyclin-dependent kinase 2 interacting protein
CLCN6 chloride channel, voltage-sensitive 6
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYTH3 cytohesin 3
DCAF4 DDB1 and CUL4 associated factor 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKFZP434C153 DKFZP434C153 protein
DNASE1L3 deoxyribonuclease I-like 3
DOK5 docking protein 5
DUSP9 dual specificity phosphatase 9
EGR2 early growth response 2
ELP6 elongator acetyltransferase complex subunit 6
ENO3 enolase 3 (beta, muscle)
EXD3 exonuclease 3'-5' domain containing 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FPGS folylpolyglutamate synthase
FSHB follicle stimulating hormone, beta polypeptide
GLB1L galactosidase, beta 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR21 G protein-coupled receptor 21
GPR75 G protein-coupled receptor 75
HHAT hedgehog acyltransferase
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
IFNA17 interferon, alpha 17
IL24 interleukin 24
IL32 interleukin 32
IL6 interleukin 6
INO80D INO80 complex subunit D
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIAA0754 KIAA0754
KIFC3 kinesin family member C3
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
KRT86 keratin 86, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC100287590 uncharacterized LOC100287590
LOC100294391 uncharacterized LOC100294391
LRRC2 leucine rich repeat containing 2
MEF2D myocyte enhancer factor 2D
MILR1 mast cell immunoglobulin-like receptor 1
MMP13 matrix metallopeptidase 13
MON1B MON1 secretory trafficking family member B
MVD mevalonate (diphospho) decarboxylase
NAT6 N-acetyltransferase 6 (GCN5-related)
NLGN1 neuroligin 1
NSUN6 NOP2/Sun domain family, member 6
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OXCT2 3-oxoacid CoA transferase 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE12 phosphodiesterase 12
PICK1 protein interacting with PRKCA 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRB3 proline-rich protein BstNI subfamily 3
PRKCE protein kinase C, epsilon
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
RAB3D RAB3D, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFPL1S RFPL1 antisense RNA 1
RNF122 ring finger protein 122
RNF39 ring finger protein 39
S1PR1 sphingosine-1-phosphate receptor 1
SAYSD1 SAYSVFN motif domain containing 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SPTBN2 spectrin, beta, non-erythrocytic 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAOK1 TAO kinase 1
THRB thyroid hormone receptor, beta
TM6SF1 transmembrane 6 superfamily member 1
TMEM74B transmembrane protein 74B
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRAC T cell receptor alpha constant
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA4B tubulin, alpha 4b
WDR4 WD repeat domain 4
WDR78 WD repeat domain 78
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF234 zinc finger protein 234
ZNF334 zinc finger protein 334
ZNF573 zinc finger protein 573