CP-690334-01-3823 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the CP-690334-01-3823 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABI2 abl-interactor 2
ACRV1 acrosomal vesicle protein 1
ADRA1A adrenoceptor alpha 1A
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAIAP3 BAI1-associated protein 3
BAMBI BMP and activin membrane-bound inhibitor
BIRC7 baculoviral IAP repeat containing 7
C7ORF69 chromosome 7 open reading frame 69
CADM3 cell adhesion molecule 3
CALML3 calmodulin-like 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFAP70 cilia and flagella associated protein 70
CHN2 chimerin 2
CLU clusterin
CNGA1 cyclic nucleotide gated channel alpha 1
CREBZF CREB/ATF bZIP transcription factor
CSF1R colony stimulating factor 1 receptor
CTGF connective tissue growth factor
CTNS cystinosin, lysosomal cystine transporter
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLG4 discs, large homolog 4 (Drosophila)
DOK4 docking protein 4
DRD5 dopamine receptor D5
EYA3 EYA transcriptional coactivator and phosphatase 3
FLJ11292
FRZB frizzled-related protein
GRM7 glutamate receptor, metabotropic 7
HAL histidine ammonia-lyase
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIST3H2A histone cluster 3, H2a
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL32 interleukin 32
INPP5J inositol polyphosphate-5-phosphatase J
INSIG1 insulin induced gene 1
JAG1 jagged 1
JUND jun D proto-oncogene
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KITLG KIT ligand
LDLR low density lipoprotein receptor
LINC00472 long intergenic non-protein coding RNA 472
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED25 mediator complex subunit 25
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MMP1 matrix metallopeptidase 1
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MORN1 MORN repeat containing 1
MPZ myelin protein zero
MT1H metallothionein 1H
NUP188 nucleoporin 188kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PADI2 peptidyl arginine deiminase, type II
PDE4DIP phosphodiesterase 4D interacting protein
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PML promyelocytic leukemia
PSG9 pregnancy specific beta-1-glycoprotein 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB30 RAB30, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
RECK reversion-inducing-cysteine-rich protein with kazal motifs
REST RE1-silencing transcription factor
RND1 Rho family GTPase 1
SCN4A sodium channel, voltage gated, type IV alpha subunit
SELPLG selectin P ligand
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT4 sirtuin 4
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMG7 SMG7 nonsense mediated mRNA decay factor
TACSTD2 tumor-associated calcium signal transducer 2
TEX14 testis expressed 14
TGM4 transglutaminase 4
THAP3 THAP domain containing, apoptosis associated protein 3
TMEM242 transmembrane protein 242
TMEM257 transmembrane protein 257
TMOD1 tropomodulin 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TP53I11 tumor protein p53 inducible protein 11
TRIM36 tripartite motif containing 36
TRIM9 tripartite motif containing 9
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VWA5A von Willebrand factor A domain containing 5A
ZER1 zyg-11 related, cell cycle regulator

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAP2 ArfGAP with dual PH domains 2
ADGRL2 adhesion G protein-coupled receptor L2
AMIGO2 adhesion molecule with Ig-like domain 2
APOL6 apolipoprotein L, 6
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARL14 ADP-ribosylation factor-like 14
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
CBS cystathionine-beta-synthase
CCDC9 coiled-coil domain containing 9
CCNK cyclin K
CD70 CD70 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLDN8 claudin 8
CLSTN3 calsyntenin 3
COPZ2 coatomer protein complex, subunit zeta 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMBT1 deleted in malignant brain tumors 1
DUSP2 dual specificity phosphatase 2
EHF ets homologous factor
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EPN1 epsin 1
EREG epiregulin
EXOC6B exocyst complex component 6B
FLJ21369 uncharacterized protein FLJ21369
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBX2 gastrulation brain homeobox 2
GEMIN8 gem (nuclear organelle) associated protein 8
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR21 G protein-coupled receptor 21
GPR4 G protein-coupled receptor 4
GREM1 gremlin 1, DAN family BMP antagonist
HAS2 hyaluronan synthase 2
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
IL24 interleukin 24
IL33 interleukin 33
IL6 interleukin 6
IL7R interleukin 7 receptor
INHBA inhibin, beta A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD17 potassium channel tetramerization domain containing 17
KLHL25 kelch-like family member 25
LIF leukemia inhibitory factor
LRRK1 leucine-rich repeat kinase 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYPD1 LY6/PLAUR domain containing 1
MDM4 MDM4, p53 regulator
MMP3 matrix metallopeptidase 3
MT1M metallothionein 1M
NDNF neuron-derived neurotrophic factor
NT5M 5',3'-nucleotidase, mitochondrial
OXCT2 3-oxoacid CoA transferase 2
PALMD palmdelphin
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIP prolactin-induced protein
POM121 POM121 transmembrane nucleoporin
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTGFR prostaglandin F receptor (FP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PXMP4 peroxisomal membrane protein 4, 24kDa
REM1 RAS (RAD and GEM)-like GTP-binding 1
RLN1 relaxin 1
RNF43 ring finger protein 43
RUNX1-IT1 RUNX1 intronic transcript 1
SALL2 spalt-like transcription factor 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STXBP5L syntaxin binding protein 5-like
TAOK1 TAO kinase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TENM4 teneurin transmembrane protein 4
TET3 tet methylcytosine dioxygenase 3
TGFB3 transforming growth factor, beta 3
THRB thyroid hormone receptor, beta
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAC T cell receptor alpha constant
TRIM16 tripartite motif containing 16
ZFHX2 zinc finger homeobox 2
ZHX2 zinc fingers and homeoboxes 2
ZNF219 zinc finger protein 219
ZNF248 zinc finger protein 248
ZNF532 zinc finger protein 532
ZNF573 zinc finger protein 573
ZNF629 zinc finger protein 629