CP-645525-01-7515 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the CP-645525-01-7515 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI1 abl-interactor 1
ACBD4 acyl-CoA binding domain containing 4
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AJAP1 adherens junctions associated protein 1
ALPK1 alpha-kinase 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATF2 activating transcription factor 2
BTN2A2 butyrophilin, subfamily 2, member A2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC87 coiled-coil domain containing 87
CDON cell adhesion associated, oncogene regulated
CLIC4 chloride intracellular channel 4
CLIP1 CAP-GLY domain containing linker protein 1
CLSPN claspin
CRHR1 corticotropin releasing hormone receptor 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTSV cathepsin V
CYB561 cytochrome b561
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAH17 dynein, axonemal, heavy chain 17
DUSP10 dual specificity phosphatase 10
EPHA2 EPH receptor A2
EPOR erythropoietin receptor
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
EVA1B eva-1 homolog B (C. elegans)
EXPH5 exophilin 5
FAM214B family with sequence similarity 214, member B
FKBP8 FK506 binding protein 8, 38kDa
GLS2 glutaminase 2 (liver, mitochondrial)
HIST1H2AB histone cluster 1, H2ab
HIST1H3I histone cluster 1, H3i
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI35 interferon-induced protein 35
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KLF9 Kruppel-like factor 9
LDB3 LIM domain binding 3
LPAR2 lysophosphatidic acid receptor 2
LPIN1 lipin 1
LRRC49 leucine rich repeat containing 49
MAPK7 mitogen-activated protein kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
MRPL44 mitochondrial ribosomal protein L44
MSL3 male-specific lethal 3 homolog (Drosophila)
MT1H metallothionein 1H
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCRL oculocerebrorenal syndrome of Lowe
OGFR opioid growth factor receptor
PAIP2B poly(A) binding protein interacting protein 2B
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF3 polycomb group ring finger 3
PLK3 polo-like kinase 3
POM121 POM121 transmembrane nucleoporin
POT1 protection of telomeres 1
PRAMEF11 PRAME family member 11
PRLR prolactin receptor
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RARS arginyl-tRNA synthetase
REEP2 receptor accessory protein 2
RHBG Rh family, B glycoprotein (gene/pseudogene)
RRBP1 ribosome binding protein 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SNIP1 Smad nuclear interacting protein 1
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
STX6 syntaxin 6
SYNPO synaptopodin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS3 thrombospondin 3
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC2 tuberous sclerosis 2
TSC22D2 TSC22 domain family, member 2
UBXN1 UBX domain protein 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNK1 WNK lysine deficient protein kinase 1
ZNF318 zinc finger protein 318
ZNF35 zinc finger protein 35
ZNF37BP zinc finger protein 37B, pseudogene
ZNF609 zinc finger protein 609
ZNF710 zinc finger protein 710
ZNF862 zinc finger protein 862
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
APOC1 apolipoprotein C-I
ARC activity-regulated cytoskeleton-associated protein
ARPIN actin-related protein 2/3 complex inhibitor
ATP13A2 ATPase type 13A2
C11ORF80 chromosome 11 open reading frame 80
C17ORF53 chromosome 17 open reading frame 53
C1ORF56 chromosome 1 open reading frame 56
C5 complement component 5
C5AR1 complement component 5a receptor 1
CCNE1 cyclin E1
CCNL2 cyclin L2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CEL carboxyl ester lipase
CRELD1 cysteine-rich with EGF-like domains 1
CST4 cystatin S
CSTA cystatin A (stefin A)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DHODH dihydroorotate dehydrogenase (quinone)
DMBT1 deleted in malignant brain tumors 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
ELL elongation factor RNA polymerase II
EXD3 exonuclease 3'-5' domain containing 3
FAM188A family with sequence similarity 188, member A
FAP fibroblast activation protein, alpha
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGD1 FYVE, RhoGEF and PH domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPR68 G protein-coupled receptor 68
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIST1H1D histone cluster 1, H1d
HIST1H2AE histone cluster 1, H2ae
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC5 homeobox C5
IL10RB interleukin 10 receptor, beta
INPP1 inositol polyphosphate-1-phosphatase
IRX4 iroquois homeobox 4
KLK8 kallikrein-related peptidase 8
KREMEN2 kringle containing transmembrane protein 2
KRT15 keratin 15, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LRP6 low density lipoprotein receptor-related protein 6
LRRC61 leucine rich repeat containing 61
LTC4S leukotriene C4 synthase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEX3C mex-3 RNA binding family member C
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MT3 metallothionein 3
NOL10 nucleolar protein 10
NOTCH4 notch 4
NPY5R neuropeptide Y receptor Y5
OCA2 oculocutaneous albinism II
OTUD3 OTU deubiquitinase 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKD2L1 polycystic kidney disease 2-like 1
PLCD1 phospholipase C, delta 1
PMP22 peripheral myelin protein 22
POMT2 protein-O-mannosyltransferase 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRLH prolactin releasing hormone
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTPRM protein tyrosine phosphatase, receptor type, M
RAB33B RAB33B, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RABL3 RAB, member of RAS oncogene family-like 3
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL23AP32 ribosomal protein L23a pseudogene 32
RUSC2 RUN and SH3 domain containing 2
SIPA1 signal-induced proliferation-associated 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPAG4 sperm associated antigen 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRA6 stimulated by retinoic acid 6
TBC1D2 TBC1 domain family, member 2
TBC1D31 TBC1 domain family, member 31
TCTN2 tectonic family member 2
TMPRSS4 transmembrane protease, serine 4
TSC22D4 TSC22 domain family, member 4
ZC3H3 zinc finger CCCH-type containing 3
ZMAT5 zinc finger, matrin-type 5
ZNF136 zinc finger protein 136
ZNF211 zinc finger protein 211
ZNF219 zinc finger protein 219
ZNF446 zinc finger protein 446
ZNF586 zinc finger protein 586
ZNF623 zinc finger protein 623