CLSPN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description claspin|The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 63967)
External Link http://www.ncbi.nlm.nih.gov/gene/63967
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Genes

36 interacting proteins for CLSPN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDK9 cyclin-dependent kinase 9
CEP250 centrosomal protein 250kDa
CHEK1 checkpoint kinase 1
FBXW11 F-box and WD repeat domain containing 11
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
LTA lymphotoxin alpha
MSH6 mutS homolog 6
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
RAD17 RAD17 homolog (S. pombe)
RAD9A RAD9 homolog A (S. pombe)
RPA2 replication protein A2, 32kDa
SFN stratifin
SUMO2 small ubiquitin-like modifier 2
TIMELESS timeless circadian clock
UBC ubiquitin C
USP28 ubiquitin specific peptidase 28
USP29 ubiquitin specific peptidase 29
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta