CD40 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD40 molecule, TNF receptor superfamily member 5|This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 958)
External Link http://www.ncbi.nlm.nih.gov/gene/958
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Genes

106 interacting proteins for CD40 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRL4 adhesion G protein-coupled receptor L4
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BSG basigin (Ok blood group)
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD40LG CD40 ligand
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CD63 CD63 molecule
CDC40 cell division cycle 40
CLDND1 claudin domain containing 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ERP44 endoplasmic reticulum protein 44
FAP fibroblast activation protein, alpha
FBL fibrillarin
GLMP glycosylated lysosomal membrane protein
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
ICAM2 intercellular adhesion molecule 2
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL13RA2 interleukin 13 receptor, alpha 2
IL4R interleukin 4 receptor
JAK3 Janus kinase 3
KATNA1 katanin p60 (ATPase containing) subunit A 1
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LNPEP leucyl/cystinyl aminopeptidase
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MPZL1 myelin protein zero-like 1
MPZL2 myelin protein zero-like 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYCBP MYC binding protein
NCOA6 nuclear receptor coactivator 6
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NPTN neuroplastin
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPAP2C phosphatidic acid phosphatase type 2C
PRNP prion protein
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTPRJ protein tyrosine phosphatase, receptor type, J
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC5 replication factor C (activator 1) 5, 36.5kDa
RIPK2 receptor-interacting serine-threonine kinase 2
RNF219 ring finger protein 219
SCARB2 scavenger receptor class B, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC30A7 solute carrier family 30 (zinc transporter), member 7
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A3 solute carrier family 43, member 3
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPPL2A signal peptide peptidase like 2A
STAT5A signal transducer and activator of transcription 5A
SUMO1 small ubiquitin-like modifier 1
SYPL1 synaptophysin-like 1
TANK TRAF family member-associated NFKB activator
TDP2 tyrosyl-DNA phosphodiesterase 2
TMEM181 transmembrane protein 181
TMEM206 transmembrane protein 206
TMEM87A transmembrane protein 87A
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSPAN3 tetraspanin 3
TXN thioredoxin
UBE2N ubiquitin-conjugating enzyme E2N
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
USP15 ubiquitin specific peptidase 15
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6