CD4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD4 molecule|This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 920)
External Link http://www.ncbi.nlm.nih.gov/gene/920
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Genes

166 interacting proteins for CD4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACTB actin, beta
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
ANXA2 annexin A2
ANXA6 annexin A6
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD2 CD2 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CD53 CD53 molecule
CD80 CD80 molecule
CD81 CD81 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CTSD cathepsin D
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DBNL drebrin-like
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPP4 dipeptidyl-peptidase 4
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3I eukaryotic translation initiation factor 3, subunit I
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4A2 eukaryotic translation initiation factor 4A2
ENO1 enolase 1, (alpha)
EPS15 epidermal growth factor receptor pathway substrate 15
FARSB phenylalanyl-tRNA synthetase, beta subunit
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FKBP1A FK506 binding protein 1A, 12kDa
FYB FYN binding protein
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRAP2 GRB2-related adaptor protein 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIST1H2BF histone cluster 1, H2bf
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL16 interleukin 16
IL2RA interleukin 2 receptor, alpha
INPPL1 inositol polyphosphate phosphatase-like 1
ITK IL2-inducible T-cell kinase
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KPNB1 karyopherin (importin) beta 1
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
MME membrane metallo-endopeptidase
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NCL nucleolin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PHB prohibitin
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLCG1 phospholipase C, gamma 1
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKCQ protein kinase C, theta
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAN RAN, member RAS oncogene family
RANBP9 RAN binding protein 9
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RPL11 ribosomal protein L11
RPL18 ribosomal protein L18
RPL22 ribosomal protein L22
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPS10 ribosomal protein S10
RPS12 ribosomal protein S12
RPS13 ribosomal protein S13
RPS18 ribosomal protein S18
RPS19 ribosomal protein S19
RPS24 ribosomal protein S24
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RPSA ribosomal protein SA
SELL selectin L
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPHK1 sphingosine kinase 1
SSRP1 structure specific recognition protein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYK spleen tyrosine kinase
TFRC transferrin receptor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNPO1 transportin 1
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
UBB ubiquitin B
UBC ubiquitin C
UBL7 ubiquitin-like 7
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VIM vimentin
YBX1 Y box binding protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa