C-75-6399 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the C-75-6399 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADGRL2 adhesion G protein-coupled receptor L2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APC adenomatous polyposis coli
APOM apolipoprotein M
ATP10A ATPase, class V, type 10A
BAIAP3 BAI1-associated protein 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1ORF54 chromosome 1 open reading frame 54
C1ORF61 chromosome 1 open reading frame 61
C20ORF195 chromosome 20 open reading frame 195
CA14 carbonic anhydrase XIV
CD4 CD4 molecule
CDC42 cell division cycle 42
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CERS4 ceramide synthase 4
CLEC11A C-type lectin domain family 11, member A
CLIC5 chloride intracellular channel 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
DCAKD dephospho-CoA kinase domain containing
DDN dendrin
DLX2 distal-less homeobox 2
DOCK10 dedicator of cytokinesis 10
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP2 dual specificity phosphatase 2
ECE1 endothelin converting enzyme 1
ESRRG estrogen-related receptor gamma
FAM49B family with sequence similarity 49, member B
FBXL7 F-box and leucine-rich repeat protein 7
FGFR4 fibroblast growth factor receptor 4
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GADD45G growth arrest and DNA-damage-inducible, gamma
GUCA1A guanylate cyclase activator 1A (retina)
HOXB2 homeobox B2
HOXD1 homeobox D1
HPCAL4 hippocalcin like 4
HR hair growth associated
ICAM1 intercellular adhesion molecule 1
IGFLR1 IGF-like family receptor 1
IL12RB1 interleukin 12 receptor, beta 1
INVS inversin
ITGA10 integrin, alpha 10
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDM5D lysine (K)-specific demethylase 5D
KLHL1 kelch-like family member 1
KLHL25 kelch-like family member 25
KRT7 keratin 7, type II
KRT86 keratin 86, type II
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOXL3 lysyl oxidase-like 3
LRP1 low density lipoprotein receptor-related protein 1
MAGOH2P mago-nashi homolog 2, pseudogene
MAP2K7 mitogen-activated protein kinase kinase 7
MAP7D3 MAP7 domain containing 3
MFAP3L microfibrillar-associated protein 3-like
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NCALD neurocalcin delta
NPR3 natriuretic peptide receptor 3
PDCD2 programmed cell death 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAC4 placenta-specific 4
PLXNB2 plexin B2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RB1 retinoblastoma 1
RGS11 regulator of G-protein signaling 11
RHBDD3 rhomboid domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF126P1 ring finger protein 126 pseudogene 1
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCNN1B sodium channel, non voltage gated 1 beta subunit
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLITRK5 SLIT and NTRK-like family, member 5
SMAD5-AS1 SMAD5 antisense RNA 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPAG8 sperm associated antigen 8
SPINK5 serine peptidase inhibitor, Kazal type 5
SPN sialophorin
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SULF1 sulfatase 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBXAS1 thromboxane A synthase 1 (platelet)
TDRKH tudor and KH domain containing
TLN2 talin 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TTLL7 tubulin tyrosine ligase-like family member 7
USP20 ubiquitin specific peptidase 20
WNT1 wingless-type MMTV integration site family, member 1

decreased expression

Symbol Name
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP19 Rho GTPase activating protein 19
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B9D2 B9 protein domain 2
BCHE butyrylcholinesterase
CBX7 chromobox homolog 7
CD33 CD33 molecule
CDIP1 cell death-inducing p53 target 1
CGREF1 cell growth regulator with EF-hand domain 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CLSPN claspin
CSRNP3 cysteine-serine-rich nuclear protein 3
CUL9 cullin 9
DISC1 disrupted in schizophrenia 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DSCAM Down syndrome cell adhesion molecule
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHX2 epoxide hydrolase 2, cytoplasmic
EPN1 epsin 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO31 F-box protein 31
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS8 growth arrest-specific 8
GPATCH2L G patch domain containing 2-like
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HGFAC HGF activator
HIRA histone cell cycle regulator
HIST1H2AL histone cluster 1, H2al
HIST1H3A histone cluster 1, H3a
HLX H2.0-like homeobox
KAT5 K(lysine) acetyltransferase 5
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KIF3A kinesin family member 3A
KLF3 Kruppel-like factor 3 (basic)
LAMC3 laminin, gamma 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMTK2 lemur tyrosine kinase 2
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MPZ myelin protein zero
MRPS18C mitochondrial ribosomal protein S18C
MVD mevalonate (diphospho) decarboxylase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NUP62CL nucleoporin 62kDa C-terminal like
OLFML2B olfactomedin-like 2B
OR1D2 olfactory receptor, family 1, subfamily D, member 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI2 peptidyl arginine deiminase, type II
PCDHGA8 protocadherin gamma subfamily A, 8
PDE8B phosphodiesterase 8B
PENK proenkephalin
PGPEP1 pyroglutamyl-peptidase I
PID1 phosphotyrosine interaction domain containing 1
PKD2L1 polycystic kidney disease 2-like 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PWAR5 Prader Willi/Angelman region RNA 5
RAB4B RAB4B, member RAS oncogene family
RBMS3 RNA binding motif, single stranded interacting protein 3
RETN resistin
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RND1 Rho family GTPase 1
RPAP1 RNA polymerase II associated protein 1
RUNX1-IT1 RUNX1 intronic transcript 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SRD5A3 steroid 5 alpha-reductase 3
SSBP3 single stranded DNA binding protein 3
SULT4A1 sulfotransferase family 4A, member 1
TAOK1 TAO kinase 1
TFF2 trefoil factor 2
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOP3B topoisomerase (DNA) III beta
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC31 tetratricopeptide repeat domain 31
TXK TXK tyrosine kinase
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
VNN2 vanin 2
YY2 YY2 transcription factor
ZFHX2 zinc finger homeobox 2
ZNF141 zinc finger protein 141
ZNF280D zinc finger protein 280D
ZNF586 zinc finger protein 586
ZNF639 zinc finger protein 639
ZNF667 zinc finger protein 667