Brucellosis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue. (Human Disease Ontology, DOID_11077)
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Genes

32 genes associated with the Brucellosis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD28 CD28 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL8 chemokine (C-X-C motif) ligand 8
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
HLA-B major histocompatibility complex, class I, B
IFNG interferon, gamma
IL10 interleukin 10
IL12B interleukin 12B
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
LMPH1B Lymphedema, hereditary, IB
MBL2 mannose-binding lectin (protein C) 2, soluble
NOS2 nitric oxide synthase 2, inducible
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
SELL selectin L
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor