Brain Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

319 genes associated with the Brain Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM33 ADAM metallopeptidase domain 33
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALAD aminolevulinate dehydratase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX5 arachidonate 5-lipoxygenase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AR androgen receptor
ARCN1 archain 1
ARFRP1 ADP-ribosylation factor related protein 1
ATM ATM serine/threonine kinase
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCORL1 BCL6 corepressor-like 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTBD2 BTB (POZ) domain containing 2
C1QA complement component 1, q subcomponent, A chain
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CBS cystathionine-beta-synthase
CCDC26 CCDC26 long non-coding RNA
CCND1 cyclin D1
CCND2 cyclin D2
CCNH cyclin H
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD2 CD2 molecule
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLPTM1L CLPTM1-like
COMT catechol-O-methyltransferase
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
D2HGDH D-2-hydroxyglutarate dehydrogenase
DCLRE1C DNA cross-link repair 1C
DMBT1 deleted in malignant brain tumors 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EME1 essential meiotic structure-specific endonuclease 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
EXO1 exonuclease 1
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FLT3 fms-related tyrosine kinase 3
FMO1 flavin containing monooxygenase 1
FMO3 flavin containing monooxygenase 3
GEN1 GEN1 Holliday junction 5' flap endonuclease
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GPX1 glutathione peroxidase 1
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM1 glutamate receptor, metabotropic 1
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
H3F3A H3 histone, family 3A
HARS histidyl-tRNA synthetase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HMGA2 high mobility group AT-hook 2
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFBP3 insulin-like growth factor binding protein 3
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL27 interleukin 27
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL7 interleukin 7
INHBC inhibin, beta C
IRGM immunity-related GTPase family, M
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LOX lysyl oxidase
LPO lactoperoxidase
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC4B leucine rich repeat containing 4B
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR146A microRNA 146a
MIR149 microRNA 149
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MT-TS1 tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUS81 MUS81 structure-specific endonuclease subunit
MUTYH mutY homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NF1 neurofibromin 1
NMUR1 neuromedin U receptor 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGG1 8-oxoguanine DNA glycosylase
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene)
POLB polymerase (DNA directed), beta
POMT1 protein-O-mannosyltransferase 1
PON1 paraoxonase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDM14 PR domain containing 14
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT8 protein arginine methyltransferase 8
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51B RAD51 paralog B
RAD51L3-RFFL RAD51L3-RFFL readthrough
RAD52 RAD52 homolog (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG1 recombination activating gene 1
RB1 retinoblastoma 1
RBBP6 retinoblastoma binding protein 6
RECQL4 RecQ protein-like 4
REN renin
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
RNR1 RNA, ribosomal cluster 1
RPA3 replication protein A3, 14kDa
RPA4 replication protein A4, 30kDa
RTEL1 regulator of telomere elongation helicase 1
RTEL1-TNFRSF6B RTEL1-TNFRSF6B readthrough (NMD candidate)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCN1B sodium channel, voltage gated, type I beta subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SETD2 SET domain containing 2
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A4RG SLC2A4 regulator
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
SMAD3 SMAD family member 3
SMAD6 SMAD family member 6
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SOX5 SRY (sex determining region Y)-box 5
SPOP speckle-type POZ protein
SSBP2 single-stranded DNA binding protein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIM2 stromal interaction molecule 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYK spleen tyrosine kinase
TCN2 transcobalamin II
TERT telomerase reverse transcriptase
TLR4 toll-like receptor 4
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TXN thioredoxin
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WWOX WW domain containing oxidoreductase
XDH xanthine dehydrogenase
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB46 zinc finger and BTB domain containing 46
ZGPAT zinc finger, CCCH-type with G patch domain
ZNF350 zinc finger protein 350
ZPBP2 zona pellucida binding protein 2