Brain Ischemia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

369 genes associated with the Brain Ischemia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHCY adenosylhomocysteinase
AIM1 absent in melanoma 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPTL3 angiopoietin-like 3
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AQP10 aquaporin 10
AR androgen receptor
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASTN2 astrotactin 2
BCAN brevican
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BHMT betaine--homocysteine S-methyltransferase
BHMT2 betaine--homocysteine S-methyltransferase 2
C1ORF167 chromosome 1 open reading frame 167
C3 complement component 3
C5 complement component 5
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN10 calpain 10
CARD8 caspase recruitment domain family, member 8
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CILP2 cartilage intermediate layer protein 2
CLCN6 chloride channel, voltage-sensitive 6
CMA1 chymase 1, mast cell
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COG2 component of oligomeric golgi complex 2
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCC DCC netrin 1 receptor
DMXL2 Dmx-like 2
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENOSF1 enolase superfamily member 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FABP2 fatty acid binding protein 2, intestinal
FCAR Fc fragment of IgA receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCRLB Fc receptor-like B
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FMO3 flavin containing monooxygenase 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL4 follistatin-like 4
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS6 growth arrest-specific 6
GC group-specific component (vitamin D binding protein)
GCH1 GTP cyclohydrolase 1
GCKR glucokinase (hexokinase 4) regulator
GH1 growth hormone 1
GJA4 gap junction protein, alpha 4, 37kDa
GJA5 gap junction protein, alpha 5, 40kDa
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GP9 glycoprotein IX (platelet)
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GRM8 glutamate receptor, metabotropic 8
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTT1 glutathione S-transferase theta 1
HDAC9 histone deacetylase 9
HEATR5B HEAT repeat containing 5B
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPS1 Hermansky-Pudlak syndrome 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL13 interleukin 13
IL16 interleukin 16
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL36RN interleukin 36 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
KALRN kalirin, RhoGEF kinase
KCNIP4 Kv channel interacting protein 4
KCNK17 potassium channel, two pore domain subfamily K, member 17
KDR kinase insert domain receptor
KIF6 kinesin family member 6
KL klotho
KLF14 Kruppel-like factor 14
KRT5 keratin 5, type II
KRT74 keratin 74, type II
LDLR low density lipoprotein receptor
LGALS14 lectin, galactoside-binding, soluble, 14
LGALS2 lectin, galactoside-binding, soluble, 2
LIF leukemia inhibitory factor
LIMK1 LIM domain kinase 1
LIPC lipase, hepatic
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOX lysyl oxidase
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB lymphotoxin beta (TNF superfamily, member 3)
LTB4R leukotriene B4 receptor
LTC4S leukotriene C4 synthase
LY6G5B lymphocyte antigen 6 complex, locus G5B
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCF2L MCF.2 cell line derived transforming sequence-like
MCM10 minichromosome maintenance complex component 10
METTL18 methyltransferase like 18
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MGP matrix Gla protein
MIR146A microRNA 146a
MIR149 microRNA 149
MIR196A2 microRNA 196a-2
MIR499A microRNA 499a
MKI67 marker of proliferation Ki-67
MLF1 myeloid leukemia factor 1
MLXIPL MLX interacting protein-like
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTAP methylthioadenosine phosphorylase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTTP microsomal triglyceride transfer protein
MUT methylmalonyl CoA mutase
MYH15 myosin, heavy chain 15
MYOM3 myomesin 3
NGB neuroglobin
NINJ2 ninjurin 2
NLGN1 neuroligin 1
NNMT nicotinamide N-methyltransferase
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPPA natriuretic peptide A
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NT5C2 5'-nucleotidase, cytosolic II
NTNG1 netrin G1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR13G1 olfactory receptor, family 13, subfamily G, member 1
OR2A25 olfactory receptor, family 2, subfamily A, member 25
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PALLD palladin, cytoskeletal associated protein
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PEMT phosphatidylethanolamine N-methyltransferase
PGLYRP2 peptidoglycan recognition protein 2
PHACTR1 phosphatase and actin regulator 1
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAT plasminogen activator, tissue
PLIN1 perilipin 1
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRKCH protein kinase C, eta
PRKG1 protein kinase, cGMP-dependent, type I
PROCR protein C receptor, endothelial
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRRC2A proline-rich coiled-coil 2A
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTGES prostaglandin E synthase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASIP1 Ras interacting protein 1
REN renin
RNLS renalase, FAD-dependent amine oxidase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROPN1 rhophilin associated tail protein 1
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPLP0P4 ribosomal protein, large, P0 pseudogene 4
RUVBL2 RuvB-like AAA ATPase 2
S1PR1 sphingosine-1-phosphate receptor 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2B3 SH2B adaptor protein 3
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNX19 sorting nexin 19
SOAT1 sterol O-acyltransferase 1
SPATA13 spermatogenesis associated 13
SPP1 secreted phosphoprotein 1
SPTB spectrin, beta, erythrocytic
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STAT4 signal transducer and activator of transcription 4
STRN striatin, calmodulin binding protein
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAS2R50 taste receptor, type 2, member 50
TBXAS1 thromboxane A synthase 1 (platelet)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCN2 transcobalamin II
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMCO6 transmembrane and coiled-coil domains 6
TMPRSS11B transmembrane protease, serine 11B
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TTC7B tetratricopeptide repeat domain 7B
TYMS thymidylate synthetase
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
VTI1A vesicle transport through interaction with t-SNAREs 1A
VWF von Willebrand factor
WDR31 WD repeat domain 31
WDR55 WD repeat domain 55
WNK1 WNK lysine deficient protein kinase 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XYLB xylulokinase homolog (H. influenzae)
ZFHX3 zinc finger homeobox 3
ZNF132 zinc finger protein 132