Bone Resorption Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001862
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Genes

237 genes/proteins associated with the disease Bone Resorption from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PTHLH parathyroid hormone-like hormone 2.88009
CXCL2 chemokine (C-X-C motif) ligand 2 2.88009
AHR aryl hydrocarbon receptor 2.88009
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.88009
BMP7 bone morphogenetic protein 7 2.88009
PTH parathyroid hormone 2.88009
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.88009
ICAM1 intercellular adhesion molecule 1 1.80472
IL1B interleukin 1, beta 1.79579
TGFB1 transforming growth factor, beta 1 1.76501
TNF tumor necrosis factor 1.76072
VEGFA vascular endothelial growth factor A 1.73858
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.72467
FAS Fas cell surface death receptor 1.71973
MAPK1 mitogen-activated protein kinase 1 1.68953
IL10 interleukin 10 1.63205
NOS2 nitric oxide synthase 2, inducible 1.61248
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.60291
CCL2 chemokine (C-C motif) ligand 2 1.58654
SPP1 secreted phosphoprotein 1 1.57329
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.56509
TH tyrosine hydroxylase 1.53184
MAPK3 mitogen-activated protein kinase 3 1.52515
SELE selectin E 1.52413
IFNG interferon, gamma 1.51759
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.51305
IL6 interleukin 6 1.51305
FOS FBJ murine osteosarcoma viral oncogene homolog 1.49686
EGFR epidermal growth factor receptor 1.47838
BCL2 B-cell CLL/lymphoma 2 1.47296
BGLAP bone gamma-carboxyglutamate (gla) protein 1.46648
MAPK8 mitogen-activated protein kinase 8 1.46277
CCND1 cyclin D1 1.44817
VCAM1 vascular cell adhesion molecule 1 1.42859
RHOA ras homolog family member A 1.42616
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.42266
ACP5 acid phosphatase 5, tartrate resistant 1.41008
BID BH3 interacting domain death agonist 1.39702
MMP9 matrix metallopeptidase 9 1.39086
MAPK14 mitogen-activated protein kinase 14 1.37676
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.37504
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.37418
BAG3 BCL2-associated athanogene 3 1.37047
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.36476
MMP2 matrix metallopeptidase 2 1.36304
IL4 interleukin 4 1.36304
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.36133
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.35502
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.35271
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.34459
TIMP1 TIMP metallopeptidase inhibitor 1 1.3382
MCM2 minichromosome maintenance complex component 2 1.33612
FDPS farnesyl diphosphate synthase 1.33405
CAT catalase 1.32935
FSHB follicle stimulating hormone, beta polypeptide 1.32458
NGF nerve growth factor (beta polypeptide) 1.32339
BAX BCL2-associated X protein 1.31985
BCL2L1 BCL2-like 1 1.31897
SOD1 superoxide dismutase 1, soluble 1.31716
CD36 CD36 molecule (thrombospondin receptor) 1.31476
COL1A1 collagen, type I, alpha 1 1.30911
HRAS Harvey rat sarcoma viral oncogene homolog 1.29936
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.29348
NFE2L2 nuclear factor, erythroid 2-like 2 1.29041
STAR steroidogenic acute regulatory protein 1.28796
RARA retinoic acid receptor, alpha 1.28364
CYBB cytochrome b-245, beta polypeptide 1.28027
IL1A interleukin 1, alpha 1.27782
CXCL8 chemokine (C-X-C motif) ligand 8 1.27502
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.2707
EDN1 endothelin 1 1.26947
PPARG peroxisome proliferator-activated receptor gamma 1.26483
MAPK9 mitogen-activated protein kinase 9 1.26421
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.25929
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.24718
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.24687
CXCL3 chemokine (C-X-C motif) ligand 3 1.24528
XBP1 X-box binding protein 1 1.24401
NOS3 nitric oxide synthase 3 (endothelial cell) 1.24307
JUN jun proto-oncogene 1.23042
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.22821
TP53 tumor protein p53 1.22599
HMOX1 heme oxygenase 1 1.22501
CTSD cathepsin D 1.22371
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.21855
PARP1 poly (ADP-ribose) polymerase 1 1.21695
GSK3B glycogen synthase kinase 3 beta 1.21567
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.21402
CCDC174 coiled-coil domain containing 174 1.21206
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.21076
FST follistatin 1.20946
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.20361
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.20328
LDLR low density lipoprotein receptor 1.19312
HNF4A hepatocyte nuclear factor 4, alpha 1.19246
CD80 CD80 molecule 1.19246
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.18915
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.18816
CRP C-reactive protein, pentraxin-related 1.18326
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.17596
TFIP11 tuftelin interacting protein 11 1.17101
HMGB1 high mobility group box 1 1.16833
CYCS cytochrome c, somatic 1.166
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.16467
NPPA natriuretic peptide A 1.16302
BMP2 bone morphogenetic protein 2 1.16104
TFRC transferrin receptor 1.15831
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.15729
TP53INP1 tumor protein p53 inducible nuclear protein 1 1.15729
SREBF1 sterol regulatory element binding transcription factor 1 1.15627
LOX lysyl oxidase 1.15357
EGR1 early growth response 1 1.15256
OXTR oxytocin receptor 1.15022
JUND jun D proto-oncogene 1.14781
DUSP1 dual specificity phosphatase 1 1.14713
IL2 interleukin 2 1.14507
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.14438
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.13929
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.13862
RGS2 regulator of G-protein signaling 2 1.13758
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.13586
MPO myeloperoxidase 1.13484
IGF1 insulin-like growth factor 1 (somatomedin C) 1.13347
NOX1 NADPH oxidase 1 1.13143
SMAD1 SMAD family member 1 1.13143
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.13109
CLK1 CDC-like kinase 1 1.13075
PTK2 protein tyrosine kinase 2 1.12906
DDIT3 DNA-damage-inducible transcript 3 1.12703
CHUK conserved helix-loop-helix ubiquitous kinase 1.12426
CCL3 chemokine (C-C motif) ligand 3 1.12185
GADD45B growth arrest and DNA-damage-inducible, beta 1.12082
GCLM glutamate-cysteine ligase, modifier subunit 1.11501
ANGPTL4 angiopoietin-like 4 1.11466
IGF2 insulin-like growth factor 2 1.1129
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.1129
SH3BP4 SH3-domain binding protein 4 1.10907
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.10872
IL12B interleukin 12B 1.10803
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.10734
COL3A1 collagen, type III, alpha 1 1.10699
FN1 fibronectin 1 1.10699
ATF3 activating transcription factor 3 1.10699
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.10665
TICAM1 toll-like receptor adaptor molecule 1 1.10246
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 1.10175
SOD2 superoxide dismutase 2, mitochondrial 1.10104
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.10069
GSR glutathione reductase 1.10033
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.09927
BDNF brain-derived neurotrophic factor 1.09646
MMP13 matrix metallopeptidase 13 1.09332
INS insulin 1.0919
CXCR4 chemokine (C-X-C motif) receptor 4 1.0919
GPX1 glutathione peroxidase 1 1.09011
ACYP1 acylphosphatase 1, erythrocyte (common) type 1.08975
TRIB3 tribbles pseudokinase 3 1.08762
CTSB cathepsin B 1.08619
SP1 Sp1 transcription factor 1.08442
SOX13 SRY (sex determining region Y)-box 13 1.08372
PRDX3 peroxiredoxin 3 1.08337
ATF4 activating transcription factor 4 1.08301
SNAI1 snail family zinc finger 1 1.08055
FKBP4 FK506 binding protein 4, 59kDa 1.08055
MTA1 metastasis associated 1 1.07768
CD14 CD14 molecule 1.07768
TF transferrin 1.07732
CD44 CD44 molecule (Indian blood group) 1.07625
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.07553
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.07553
DDIT4 DNA-damage-inducible transcript 4 1.07482
LEP leptin 1.07376
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.0734
FABP4 fatty acid binding protein 4, adipocyte 1.0734
EFNA1 ephrin-A1 1.07305
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.07305
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.07093
BCL6 B-cell CLL/lymphoma 6 1.06844
TFAM transcription factor A, mitochondrial 1.06844
FAM214A family with sequence similarity 214, member A 1.06698
PECAM1 platelet/endothelial cell adhesion molecule 1 1.06588
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.06406
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.0637
HK2 hexokinase 2 1.06333
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.06333
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 1.06152
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.06116
MANEA mannosidase, endo-alpha 1.06116
PLAU plasminogen activator, urokinase 1.05864
TSC22D2 TSC22 domain family, member 2 1.05648
EZR ezrin 1.05423
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.05312
NMU neuromedin U 1.05126
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.05052
SESN2 sestrin 2 1.04941
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.04831
PER2 period circadian clock 2 1.04721
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.04721
GSTO1 glutathione S-transferase omega 1 1.04684
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.04574
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.04574
CSF1 colony stimulating factor 1 (macrophage) 1.04501
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.04314
COX1 1.04276
PSAT1 phosphoserine aminotransferase 1 1.04276
THPO thrombopoietin 1.04163
TBK1 TANK-binding kinase 1 1.04163
CCNB1 cyclin B1 1.04163
PPID peptidylprolyl isomerase D 1.04126
SMTN smoothelin 1.04126
JAK1 Janus kinase 1 1.04051
ENO2 enolase 2 (gamma, neuronal) 1.03864
MFN1 mitofusin 1 1.03641
FADD Fas (TNFRSF6)-associated via death domain 1.03419
UBE3B ubiquitin protein ligase E3B 1.03382
KDM5B lysine (K)-specific demethylase 5B 1.03159
ANXA3 annexin A3 1.02971
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.02821
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.02708
MMP1 matrix metallopeptidase 1 1.02485
CTGF connective tissue growth factor 1.02485
ALB albumin 1.02447
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.0204
ADORA2A adenosine A2a receptor 1.01966
BTG1 B-cell translocation gene 1, anti-proliferative 1.01966
IL18 interleukin 18 1.01928
IL5 interleukin 5 1.01928
MYOF myoferlin 1.0189
SLK STE20-like kinase 1.01852
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 1.01814
BAD BCL2-associated agonist of cell death 1.01776
ATF2 activating transcription factor 2 1.01587
TLR4 toll-like receptor 4 1.01587
IRF3 interferon regulatory factor 3 1.01512
STAT1 signal transducer and activator of transcription 1, 91kDa 1.01324
CLU clusterin 1.01099
COX17 COX17 cytochrome c oxidase copper chaperone 1.01025