Bone Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

117 genes associated with the Bone Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
APC adenomatous polyposis coli
AR androgen receptor
BIK BCL2-interacting killer (apoptosis-inducing)
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C1QA complement component 1, q subcomponent, A chain
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCNH cyclin H
CD86 CD86 molecule
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
CRP C-reactive protein, pentraxin-related
CTBP2 C-terminal binding protein 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
FAS Fas cell surface death receptor
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNRH2 gonadotropin-releasing hormone 2
GRM4 glutamate receptor, metabotropic 4
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2R insulin-like growth factor 2 receptor
IL27 interleukin 27
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
JAZF1 JAZF zinc finger 1
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LCT lactase
LMTK2 lemur tyrosine kinase 2
LOX lysyl oxidase
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR146A microRNA 146a
MIR196A2 microRNA 196a-2
MIR499A microRNA 499a
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
MT-TS1 tRNA
MT-TV tRNA
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NKX3-1 NK3 homeobox 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPSR1-AS1 NPSR1 antisense RNA 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PCGF2 polycomb group ring finger 2
PDLIM5 PDZ and LIM domain 5
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
RECQL5 RecQ protein-like 5
RFC1 replication factor C (activator 1) 1, 145kDa
RNR1 RNA, ribosomal cluster 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SPP1 secreted phosphoprotein 1
T T, brachyury homolog (mouse)
TCF20 transcription factor 20 (AR1)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THADA thyroid adenoma associated
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TYMS thymidylate synthetase
TYR tyrosinase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3