Benzo(a)pyrene Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. (Chemical Entities of Biological Interest Ontology, CHEBI_29865)
External Link http://ctdbase.org/detail.go?type=chem&acc=D001564
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Genes

361 genes/proteins interacting with the chemical Benzo(a)pyrene from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACHE acetylcholinesterase (Yt blood group)
ACO1 aconitase 1, soluble
ACTB actin, beta
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA5 annexin A5
APOA1 apolipoprotein A-I
AR androgen receptor
ARG1 arginase 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARNT aryl hydrocarbon receptor nuclear translocator
ATF2 activating transcription factor 2
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB3 BUB3 mitotic checkpoint protein
CA3 carbonic anhydrase III
CA9 carbonic anhydrase IX
CAPG capping protein (actin filament), gelsolin-like
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CBR1 carbonyl reductase 1
CCL1 chemokine (C-C motif) ligand 1
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CD40LG CD40 ligand
CD59 CD59 molecule, complement regulatory protein
CD83 CD83 molecule
CD86 CD86 molecule
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFL1 cofilin 1 (non-muscle)
CGB chorionic gonadotropin, beta polypeptide
CHEK1 checkpoint kinase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLOCK clock circadian regulator
CLSPN claspin
COPS8 COP9 signalosome subunit 8
CORO1C coronin, actin binding protein, 1C
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYZ crystallin, zeta (quinone reductase)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAPK3 death-associated protein kinase 3
DDB2 damage-specific DNA binding protein 2, 48kDa
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DHFR dihydrofolate reductase
DMD dystrophin
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYSL3 dihydropyrimidinase-like 3
E2F1 E2F transcription factor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELANE elastase, neutrophil expressed
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
ETFB electron-transfer-flavoprotein, beta polypeptide
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCAR Fc fragment of IgA receptor
FGF2 fibroblast growth factor 2 (basic)
FGF9 fibroblast growth factor 9
FLNC filamin C, gamma
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCG glucagon
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GLOD4 glyoxalase domain containing 4
GLUD1 glutamate dehydrogenase 1
GMPS guanine monphosphate synthase
GNMT glycine N-methyltransferase
GRB2 growth factor receptor-bound protein 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HDAC1 histone deacetylase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST3H3 histone cluster 3, H3
HIST4H4 histone cluster 4, H4
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNMT histamine N-methyltransferase
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSF1 heat shock transcription factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
ICAM1 intercellular adhesion molecule 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL11 interleukin 11
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITK IL2-inducible T-cell kinase
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KEAP1 kelch-like ECH-associated protein 1
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LASP1 LIM and SH3 protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LHB luteinizing hormone beta polypeptide
LMNA lamin A/C
LMNB1 lamin B1
LPP LIM domain containing preferred translocation partner in lipoma
MAGEA1 melanoma antigen family A1
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MLANA melan-A
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYOG myogenin (myogenic factor 4)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV1 neuron navigator 1
NCF1 neutrophil cytosolic factor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRF1 nuclear respiratory factor 1
NSFL1C NSFL1 (p97) cofactor (p47)
PARP1 poly (ADP-ribose) polymerase 1
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PLEC plectin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLB polymerase (DNA directed), beta
POLG polymerase (DNA directed), gamma
POR P450 (cytochrome) oxidoreductase
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF31 pre-mRNA processing factor 31
PRPH peripherin
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGES2 prostaglandin E synthase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RB1 retinoblastoma 1
RDX radixin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF2 ring finger protein 2
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
RUVBL1 RuvB-like AAA ATPase 1
RXRA retinoid X receptor, alpha
S100A6 S100 calcium binding protein A6
SDC1 syndecan 1
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEPT9 septin 9
SF3B4 splicing factor 3b, subunit 4, 49kDa
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SP4 Sp4 transcription factor
SPI1 Spi-1 proto-oncogene
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRM spermidine synthase
SRPK1 SRSF protein kinase 1
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
SYT1 synaptotagmin I
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCF3 transcription factor 3
TFAM transcription factor A, mitochondrial
TMPO thymopoietin
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
TPM4 tropomyosin 4
TPO thyroid peroxidase
TREX1 three prime repair exonuclease 1
TUBA1C tubulin, alpha 1c
TUFM Tu translation elongation factor, mitochondrial
TWIST1 twist family bHLH transcription factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBE2N ubiquitin-conjugating enzyme E2N
UGDH UDP-glucose 6-dehydrogenase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIM vimentin
VSNL1 visinin-like 1
WNT1 wingless-type MMTV integration site family, member 1
WNT5A wingless-type MMTV integration site family, member 5A
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C