Benzene Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system. (Chemical Entities of Biological Interest Ontology, CHEBI_16716)
External Link http://ctdbase.org/detail.go?type=chem&acc=D001554
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Genes

101 genes/proteins interacting with the chemical Benzene from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ADA adenosine deaminase
AHR aryl hydrocarbon receptor
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
BAD BCL2-associated agonist of cell death
BAG1 BCL2-associated athanogene
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BRCA2 breast cancer 2, early onset
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCND1 cyclin D1
CD1B CD1b molecule
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DPP4 dipeptidyl-peptidase 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
FKBP1A FK506 binding protein 1A, 12kDa
FKBP5 FK506 binding protein 5
GJB1 gap junction protein, beta 1, 32kDa
GNRHR gonadotropin-releasing hormone receptor
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUSB glucuronidase, beta
HRH3 histamine receptor H3
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFNG interferon, gamma
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL2 interleukin 2
IL4R interleukin 4 receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP13 matrix metallopeptidase 13
MPO myeloperoxidase
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTF3 neurotrophin 3
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDX1 pancreatic and duodenal homeobox 1
PF4 platelet factor 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POR P450 (cytochrome) oxidoreductase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RAB14 RAB14, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TERT telomerase reverse transcriptase
TNF tumor necrosis factor
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TXN thioredoxin
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
VCAM1 vascular cell adhesion molecule 1
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZFP36 ZFP36 ring finger protein