Base-Excision Repair, AP Site Formation Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. (Gene Ontology, GO_0006285)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-73929
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Genes

9 proteins participating in the Base-Excision Repair, AP Site Formation pathway from the Reactome Pathways dataset.

Symbol Name
CCNO cyclin O
MBD4 methyl-CpG binding domain protein 4
MPG N-methylpurine-DNA glycosylase
MUTYH mutY homolog
NTHL1 nth endonuclease III-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
TDG thymine-DNA glycosylase
UNG uracil-DNA glycosylase