Base Excision Repair Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. (Gene Ontology, GO_0006284)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-73884
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Genes

20 proteins participating in the Base Excision Repair pathway from the Reactome Pathways dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
CCNO cyclin O
FEN1 flap structure-specific endonuclease 1
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
MBD4 methyl-CpG binding domain protein 4
MPG N-methylpurine-DNA glycosylase
MUTYH mutY homolog
NTHL1 nth endonuclease III-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PCNA proliferating cell nuclear antigen
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
TDG thymine-DNA glycosylase
UNG uracil-DNA glycosylase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1