Basal Ganglia Diseases Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001480
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Genes

191 genes/proteins associated with the disease Basal Ganglia Diseases from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MICU1 mitochondrial calcium uptake 1 2.88009
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.88009
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.88009
DRD3 dopamine receptor D3 2.88009
PDE8B phosphodiesterase 8B 2.88009
DRD2 dopamine receptor D2 2.88009
PRL prolactin 2.88009
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.88009
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.44803
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.38115
DRD1 dopamine receptor D1 2.36453
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.34625
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.26739
BDNF brain-derived neurotrophic factor 2.24789
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.24505
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.19164
FOS FBJ murine osteosarcoma viral oncogene homolog 2.16069
TNF tumor necrosis factor 2.15568
CAT catalase 2.09357
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.04319
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.0378
BCL2 B-cell CLL/lymphoma 2 2.03051
EGR1 early growth response 1 1.99596
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.96178
MAPK1 mitogen-activated protein kinase 1 1.92801
BAX BCL2-associated X protein 1.86873
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.8418
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.83895
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.82621
ARC activity-regulated cytoskeleton-associated protein 1.81958
MAPK3 mitogen-activated protein kinase 3 1.79904
POMC proopiomelanocortin 1.79408
SOD1 superoxide dismutase 1, soluble 1.77374
NOS2 nitric oxide synthase 2, inducible 1.76559
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.74421
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.74119
IL6 interleukin 6 1.73028
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.7224
TH tyrosine hydroxylase 1.72219
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.70306
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.69082
ADORA2A adenosine A2a receptor 1.66792
CRH corticotropin releasing hormone 1.65643
CREB1 cAMP responsive element binding protein 1 1.65621
TAC1 tachykinin, precursor 1 1.64326
NPY neuropeptide Y 1.64123
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.63989
GSTP1 glutathione S-transferase pi 1 1.63339
JUN jun proto-oncogene 1.58818
HRH1 histamine receptor H1 1.56019
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.55182
DRD4 dopamine receptor D4 1.53283
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.53283
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.52791
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.52693
AVP arginine vasopressin 1.52566
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.49813
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.49381
INS insulin 1.49356
PENK proenkephalin 1.49356
HOMER1 homer scaffolding protein 1 1.48993
GFAP glial fibrillary acidic protein 1.48351
HMOX1 heme oxygenase 1 1.48042
GSK3B glycogen synthase kinase 3 beta 1.47115
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.47038
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.46648
VEGFA vascular endothelial growth factor A 1.44763
CDK5 cyclin-dependent kinase 5 1.44735
FNDC4 fibronectin type III domain containing 4 1.43809
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.4332
JUNB jun B proto-oncogene 1.43157
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.42454
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.42293
ADORA1 adenosine A1 receptor 1.41965
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.41694
C10ORF10 chromosome 10 open reading frame 10 1.40036
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.40036
ACHE acetylcholinesterase (Yt blood group) 1.39674
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.39591
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.39591
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.39563
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.3931
DUSP1 dual specificity phosphatase 1 1.39254
APP amyloid beta (A4) precursor protein 1.39254
IFNG interferon, gamma 1.39226
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.39086
MAPK8 mitogen-activated protein kinase 8 1.38498
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.38156
RELN reelin 1.37075
CCND1 cyclin D1 1.36447
SOD2 superoxide dismutase 2, mitochondrial 1.35792
IL1B interleukin 1, beta 1.35647
ADCY5 adenylate cyclase 5 1.35531
OPRM1 opioid receptor, mu 1 1.34664
MAOA monoamine oxidase A 1.34227
TP53 tumor protein p53 1.34227
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.34082
NUPR1 nuclear protein, transcriptional regulator, 1 1.33375
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.32993
GAL galanin/GMAP prepropeptide 1.31119
EGR2 early growth response 2 1.30881
NGFR nerve growth factor receptor 1.30421
FAS Fas cell surface death receptor 1.28919
GRM1 glutamate receptor, metabotropic 1 1.28919
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.28765
PRKCD protein kinase C, delta 1.28734
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.28364
GRIK2 glutamate receptor, ionotropic, kainate 2 1.2818
INHBE inhibin, beta E 1.28119
MAOB monoamine oxidase B 1.27905
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.27564
PDYN prodynorphin 1.27162
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.26267
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.26267
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.2596
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.25838
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.25588
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.25557
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.25432
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.24213
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.23743
CNR1 cannabinoid receptor 1 (brain) 1.22534
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.22534
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.2208
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.22016
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.20881
OXT oxytocin/neurophysin I prepropeptide 1.20881
TAGLN transgelin 1.20622
GNAS GNAS complex locus 1.20361
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.18915
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.18882
LEP leptin 1.18783
HPN hepsin 1.18326
CES2 carboxylesterase 2 1.18059
MAP2 microtubule-associated protein 2 1.17993
EFNB3 ephrin-B3 1.17827
CYP3A cytochrome P450, family 3, subfamily A 1.17662
LHB luteinizing hormone beta polypeptide 1.17101
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 1.16866
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.16866
RGS2 regulator of G-protein signaling 2 1.16633
GDNF glial cell derived neurotrophic factor 1.16035
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.15933
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.15831
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.15189
DUSP6 dual specificity phosphatase 6 1.14541
EGFR epidermal growth factor receptor 1.14132
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.14132
CALCA calcitonin-related polypeptide alpha 1.14098
MAPK14 mitogen-activated protein kinase 14 1.13177
NGF nerve growth factor (beta polypeptide) 1.13075
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.12771
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.12391
FADS2 fatty acid desaturase 2 1.11843
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.11536
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.11501
NCAN neurocan 1.10907
NPPA natriuretic peptide A 1.10424
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.10175
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.10033
BCHE butyrylcholinesterase 1.09927
SREBF2 sterol regulatory element binding transcription factor 2 1.09646
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.09366
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.09366
CHRM1 cholinergic receptor, muscarinic 1 1.09119
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.09047
TRH thyrotropin-releasing hormone 1.08549
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.08478
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.08161
TGFB1 transforming growth factor, beta 1 1.08091
SYN2 synapsin II 1.07911
MPO myeloperoxidase 1.07553
BCL2L1 BCL2-like 1 1.07553
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.07093
DDIT3 DNA-damage-inducible transcript 3 1.06406
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.06044
RGS4 regulator of G-protein signaling 4 1.05721
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.05237
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.05015
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.04721
CCL3 chemokine (C-C motif) ligand 3 1.04647
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.04014
PRKCB protein kinase C, beta 1.03641
LDLR low density lipoprotein receptor 1.03046
CCL2 chemokine (C-C motif) ligand 2 1.02971
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.02485
SYT4 synaptotagmin IV 1.02373
GSTM1 glutathione S-transferase mu 1 1.01928
FABP1 fatty acid binding protein 1, liver 1.01814
SIGMAR1 sigma non-opioid intracellular receptor 1 1.01814
PARP1 poly (ADP-ribose) polymerase 1 1.01776