BUB1 Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description BUB1 mitotic checkpoint serine/threonine kinase|This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 699)
External Link http://www.ncbi.nlm.nih.gov/gene/699
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Genes

4 substrates of the kinase BUB1 from the curated KEA Substrates of Kinases dataset.

Symbol Name
BUB3 BUB3 mitotic checkpoint protein
CDC20 cell division cycle 20
HDAC1 histone deacetylase 1
SVIL supervillin