BTK Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description Bruton agammaglobulinemia tyrosine kinase|The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 695)
External Link http://www.ncbi.nlm.nih.gov/gene/695
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Genes

25 substrates of the kinase BTK from the curated KEA Substrates of Kinases dataset.

Symbol Name
ARHGAP17 Rho GTPase activating protein 17
BCAR1 breast cancer anti-estrogen resistance 1
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CD19 CD19 molecule
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DOK2 docking protein 2, 56kDa
EFS embryonal Fyn-associated substrate
EMB embigin
GTF2I general transcription factor IIi
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITK IL2-inducible T-cell kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PXN paxillin
STAT5A signal transducer and activator of transcription 5A
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TP53 tumor protein p53
WAS Wiskott-Aldrich syndrome