BRD-U94846492_Quinine hemisulfate salt monohydrate_SNUC5_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-U94846492_Quinine hemisulfate salt monohydrate_SNUC5_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCA calcitonin-related polypeptide alpha
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CIT citron rho-interacting serine/threonine kinase
CLGN calmegin
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CSPG4 chondroitin sulfate proteoglycan 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOK5 docking protein 5
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELMO1 engulfment and cell motility 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP6 fatty acid binding protein 6, ileal
FAM46A family with sequence similarity 46, member A
FBN2 fibrillin 2
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GCH1 GTP cyclohydrolase 1
GIMAP5 GTPase, IMAP family member 5
GPC3 glypican 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
KDM5D lysine (K)-specific demethylase 5D
KIF5C kinesin family member 5C
LAMA4 laminin, alpha 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRMP lymphoid-restricted membrane protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MAST2 microtubule associated serine/threonine kinase 2
MEP1A meprin A, alpha (PABA peptide hydrolase)
MIA melanoma inhibitory activity
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEFH neurofilament, heavy polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2A phosphatidic acid phosphatase type 2A
RABAC1 Rab acceptor 1 (prenylated)
RBPMS RNA binding protein with multiple splicing
SCD5 stearoyl-CoA desaturase 5
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SFTPD surfactant protein D
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
STOM stomatin
TCTA T-cell leukemia translocation altered
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TNNC1 troponin C type 1 (slow)
TRAF3IP2 TRAF3 interacting protein 2
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UST uronyl-2-sulfotransferase
WDR61 WD repeat domain 61
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
XPO7 exportin 7

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADAM9 ADAM metallopeptidase domain 9
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
ATP11B ATPase, class VI, type 11B
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CAV2 caveolin 2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLEC11A C-type lectin domain family 11, member A
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DEGS1 delta(4)-desaturase, sphingolipid 1
DLD dihydrolipoamide dehydrogenase
DPT dermatopontin
DSTN destrin (actin depolymerizing factor)
EBNA1BP2 EBNA1 binding protein 2
EHF ets homologous factor
ERGIC2 ERGIC and golgi 2
FAM69A family with sequence similarity 69, member A
FGFBP1 fibroblast growth factor binding protein 1
FGFR2 fibroblast growth factor receptor 2
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP8 GTP-binding protein 8 (putative)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IL10RB interleukin 10 receptor, beta
IPO13 importin 13
JMJD6 jumonji domain containing 6
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
LAP3 leucine aminopeptidase 3
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MTERF3 mitochondrial transcription termination factor 3
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NFIB nuclear factor I/B
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PDLIM3 PDZ and LIM domain 3
PDZK1IP1 PDZK1 interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLS3 plastin 3
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
PPA1 pyrophosphatase (inorganic) 1
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB32 RAB32, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SKAP2 src kinase associated phosphoprotein 2
SLC38A2 solute carrier family 38, member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRP72 signal recognition particle 72kDa
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TES testin LIM domain protein
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VCAN versican
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC6 zinc finger, DHHC-type containing 6