BRD-U94846492_Quinine hemisulfate salt monohydrate_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-U94846492_Quinine hemisulfate salt monohydrate_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AEBP1 AE binding protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BPHL biphenyl hydrolase-like (serine hydrolase)
CD163 CD163 molecule
CDK19 cyclin-dependent kinase 19
CEP57 centrosomal protein 57kDa
CHL1 cell adhesion molecule L1-like
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DLK1 delta-like 1 homolog (Drosophila)
EMX2 empty spiracles homeobox 2
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GAGE3 G antigen 3
GAS7 growth arrest-specific 7
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
KRT19 keratin 19, type I
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
MEF2C myocyte enhancer factor 2C
MKL2 MKL/myocardin-like 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MUC16 mucin 16, cell surface associated
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
PAEP progestagen-associated endometrial protein
PDE8B phosphodiesterase 8B
PEG3 paternally expressed 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RIPK4 receptor-interacting serine-threonine kinase 4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
TF transferrin
THY1 Thy-1 cell surface antigen
TMPRSS4 transmembrane protease, serine 4
TPST2 tyrosylprotein sulfotransferase 2
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
ARMCX2 armadillo repeat containing, X-linked 2
BASP1 brain abundant, membrane attached signal protein 1
C8ORF4 chromosome 8 open reading frame 4
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CELF2 CUGBP, Elav-like family member 2
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST3 cystatin C
CTGF connective tissue growth factor
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL9 chemokine (C-X-C motif) ligand 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DYNLT3 dynein, light chain, Tctex-type 3
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
IFITM1 interferon induced transmembrane protein 1
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KRT10 keratin 10, type I
KTN1 kinectin 1 (kinesin receptor)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MTCL1 microtubule crosslinking factor 1
NEBL nebulette
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLK2 polo-like kinase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RET ret proto-oncogene
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STC1 stanniocalcin 1
STK39 serine threonine kinase 39
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TNS1 tensin 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2