BRD-U94846492_Quinine hemisulfate salt monohydrate_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-U94846492_Quinine hemisulfate salt monohydrate_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACOX2 acyl-CoA oxidase 2, branched chain
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARID5B AT rich interactive domain 5B (MRF1-like)
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CEP57 centrosomal protein 57kDa
CHMP4A charged multivesicular body protein 4A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFA6 defensin, alpha 6, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
FBXO21 F-box protein 21
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FDX1 ferredoxin 1
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLT8D2 glycosyltransferase 8 domain containing 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
HLA-DRA major histocompatibility complex, class II, DR alpha
HYAL1 hyaluronoglucosaminidase 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INA internexin neuronal intermediate filament protein, alpha
IPO13 importin 13
IRF9 interferon regulatory factor 9
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIAA1462 KIAA1462
KRT19 keratin 19, type I
KRT20 keratin 20, type I
LRRC17 leucine rich repeat containing 17
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MPO myeloperoxidase
MTMR11 myotubularin related protein 11
MZB1 marginal zone B and B1 cell-specific protein
NCF2 neutrophil cytosolic factor 2
OPN3 opsin 3
ORC1 origin recognition complex, subunit 1
PBX1 pre-B-cell leukemia homeobox 1
PCDH7 protocadherin 7
PCP4 Purkinje cell protein 4
PDLIM3 PDZ and LIM domain 3
PLN phospholamban
POSTN periostin, osteoblast specific factor
PRKCI protein kinase C, iota
PRUNE prune exopolyphosphatase
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMEM30B transmembrane protein 30B
TMEM47 transmembrane protein 47
UGP2 UDP-glucose pyrophosphorylase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABHD2 abhydrolase domain containing 2
ADD1 adducin 1 (alpha)
ADGRG6 adhesion G protein-coupled receptor G6
AKAP7 A kinase (PRKA) anchor protein 7
AMD1 adenosylmethionine decarboxylase 1
ANKRD10 ankyrin repeat domain 10
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA5 annexin A5
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX6 armadillo repeat containing, X-linked 6
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CPNE3 copine III
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDF1 endothelial differentiation-related factor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ENDOG endonuclease G
ENO1 enolase 1, (alpha)
ETV5 ets variant 5
FAM134A family with sequence similarity 134, member A
FOLR1 folate receptor 1 (adult)
GAK cyclin G associated kinase
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GOLM1 golgi membrane protein 1
GOLT1B golgi transport 1B
HOXC6 homeobox C6
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MED24 mediator complex subunit 24
MFSD10 major facilitator superfamily domain containing 10
MGLL monoglyceride lipase
MSX1 msh homeobox 1
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLSCR3 phospholipid scramblase 3
PRAME preferentially expressed antigen in melanoma
PRDX4 peroxiredoxin 4
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
QDPR quinoid dihydropteridine reductase
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK5 serine peptidase inhibitor, Kazal type 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM29 tripartite motif containing 29
TSPO translocator protein (18kDa)
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase