BRD-U70626184_BI-2536_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-U70626184_BI-2536_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
EPN2 epsin 2
EXOSC4 exosome component 4
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LY6E lymphocyte antigen 6 complex, locus E
METTL7A methyltransferase like 7A
MX1 MX dynamin-like GTPase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCP4 Purkinje cell protein 4
PLEK pleckstrin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
REC8 REC8 meiotic recombination protein
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UGCG UDP-glucose ceramide glucosyltransferase
VCAM1 vascular cell adhesion molecule 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADAM9 ADAM metallopeptidase domain 9
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAALC brain and acute leukemia, cytoplasmic
BPHL biphenyl hydrolase-like (serine hydrolase)
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
CDK4 cyclin-dependent kinase 4
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL3 dihydropyrimidinase-like 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP7 fatty acid binding protein 7, brain
FAM69A family with sequence similarity 69, member A
FBXL12 F-box and leucine-rich repeat protein 12
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FST follistatin
HES1 hes family bHLH transcription factor 1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL1RAP interleukin 1 receptor accessory protein
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MELK maternal embryonic leucine zipper kinase
METTL1 methyltransferase like 1
MINA MYC induced nuclear antigen
MRPL19 mitochondrial ribosomal protein L19
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PIP prolactin-induced protein
PMM2 phosphomannomutase 2
POPDC3 popeye domain containing 3
RGS5 regulator of G-protein signaling 5
SCGB2A2 secretoglobin, family 2A, member 2
SEC63 SEC63 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SNX7 sorting nexin 7
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX2 sushi-repeat containing protein, X-linked 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM9SF3 transmembrane 9 superfamily member 3
TMEM204 transmembrane protein 204
TOX3 TOX high mobility group box family member 3
TUBB2A tubulin, beta 2A class IIa
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZNF395 zinc finger protein 395