BRD-U64521890_XMD16-144_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-U64521890_XMD16-144_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ALDOB aldolase B, fructose-bisphosphate
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C5 complement component 5
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD24 CD24 molecule
CD38 CD38 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO1C coronin, actin binding protein, 1C
CPE carboxypeptidase E
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DAPK1 death-associated protein kinase 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSC2 desmocollin 2
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPPK1 epiplakin 1
ETNK1 ethanolamine kinase 1
EZR ezrin
FAM46A family with sequence similarity 46, member A
FBXO21 F-box protein 21
FGG fibrinogen gamma chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD5 frizzled class receptor 5
G6PD glucose-6-phosphate dehydrogenase
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPX1 glutathione peroxidase 1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HPSE heparanase
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
ITGA6 integrin, alpha 6
ITM2C integral membrane protein 2C
KDM5B lysine (K)-specific demethylase 5B
KIF2C kinesin family member 2C
KLHL21 kelch-like family member 21
LDOC1 leucine zipper, down-regulated in cancer 1
LGMN legumain
LMNA lamin A/C
LPIN1 lipin 1
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MT1M metallothionein 1M
NEBL nebulette
NEFM neurofilament, medium polypeptide
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCZ protein kinase C, zeta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCOR1 REST corepressor 1
RSRP1 arginine/serine-rich protein 1
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX9 SRY (sex determining region Y)-box 9
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
STK26 serine/threonine protein kinase 26
STK3 serine/threonine kinase 3
STOM stomatin
STX12 syntaxin 12
STXBP1 syntaxin binding protein 1
TDO2 tryptophan 2,3-dioxygenase
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TOB1 transducer of ERBB2, 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TST thiosulfate sulfurtransferase (rhodanese)
TUBB2A tubulin, beta 2A class IIa
UNC13B unc-13 homolog B (C. elegans)
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
WIF1 WNT inhibitory factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG1 adhesion G protein-coupled receptor G1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
CA12 carbonic anhydrase XII
CCNA1 cyclin A1
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A2 collagen, type IV, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ERAP2 endoplasmic reticulum aminopeptidase 2
EXOSC8 exosome component 8
FAM129A family with sequence similarity 129, member A
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
HOXB7 homeobox B7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF14 kinesin family member 14
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRRC17 leucine rich repeat containing 17
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAP1L1 nucleosome assembly protein 1-like 1
NCK1 NCK adaptor protein 1
NMI N-myc (and STAT) interactor
PARP2 poly (ADP-ribose) polymerase 2
PFAS phosphoribosylformylglycinamidine synthase
PIP prolactin-induced protein
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBMS1 RNA binding motif, single stranded interacting protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
THYN1 thymocyte nuclear protein 1
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNDC9 thioredoxin domain containing 9
UNG uracil-DNA glycosylase