BRD-U64521890_XMD16-144_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-U64521890_XMD16-144_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD2 abhydrolase domain containing 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY9 adenylate cyclase 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATPIF1 ATPase inhibitory factor 1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM50A family with sequence similarity 50, member A
FBXO21 F-box protein 21
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOXC1 forkhead box C1
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GLS glutaminase
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HOOK2 hook microtubule-tethering protein 2
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGF2R insulin-like growth factor 2 receptor
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KLF10 Kruppel-like factor 10
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
MAGED2 melanoma antigen family D2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEF2C myocyte enhancer factor 2C
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPEPPS aminopeptidase puromycin sensitive
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
STOM stomatin
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TBX2 T-box 2
TDRD7 tudor domain containing 7
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TPP1 tripeptidyl peptidase I
UBE3B ubiquitin protein ligase E3B
UGCG UDP-glucose ceramide glucosyltransferase
VDAC1 voltage-dependent anion channel 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
AEBP1 AE binding protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
C3 complement component 3
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CPB1 carboxypeptidase B1 (tissue)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP3 epithelial membrane protein 3
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FXYD5 FXYD domain containing ion transport regulator 5
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HSPA14 heat shock 70kDa protein 14
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
ITM2A integral membrane protein 2A
KIAA0020 KIAA0020
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MFAP5 microfibrillar associated protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPO myeloperoxidase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NPDC1 neural proliferation, differentiation and control, 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PDE4A phosphodiesterase 4A, cAMP-specific
PDHX pyruvate dehydrogenase complex, component X
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PIP prolactin-induced protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRPF19 pre-mRNA processing factor 19
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RPP38 ribonuclease P/MRP 38kDa subunit
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAGP small cell adhesion glycoprotein
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TRBC1 T cell receptor beta constant 1
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UCK2 uridine-cytidine kinase 2
UNG uracil-DNA glycosylase
VCAN versican
WDR74 WD repeat domain 74
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)