BRD-U64521890_XMD16-144_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-U64521890_XMD16-144_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
C9ORF16 chromosome 9 open reading frame 16
CCDC92 coiled-coil domain containing 92
CCNF cyclin F
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GLS glutaminase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
IFI6 interferon, alpha-inducible protein 6
IL1RN interleukin 1 receptor antagonist
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KDM5B lysine (K)-specific demethylase 5B
KIF2C kinesin family member 2C
KLHL21 kelch-like family member 21
KRCC1 lysine-rich coiled-coil 1
LGMN legumain
NQO1 NAD(P)H dehydrogenase, quinone 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
RBKS ribokinase
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
STXBP1 syntaxin binding protein 1
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TPD52L1 tumor protein D52-like 1
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AFP alpha-fetoprotein
AHR aryl hydrocarbon receptor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BGN biglycan
C3 complement component 3
CCNA2 cyclin A2
CD302 CD302 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHEK1 checkpoint kinase 1
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CP ceruloplasmin (ferroxidase)
DCLK1 doublecortin-like kinase 1
DPYSL3 dihydropyrimidinase-like 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXOSC8 exosome component 8
FKBP11 FK506 binding protein 11, 19 kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSAP gamma-secretase activating protein
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
LEF1 lymphoid enhancer-binding factor 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MOK MOK protein kinase
MSLN mesothelin
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
PARP2 poly (ADP-ribose) polymerase 2
PCOLCE procollagen C-endopeptidase enhancer
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RPL10 ribosomal protein L10
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX10 sorting nexin 10
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TLR4 toll-like receptor 4
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIP13 thyroid hormone receptor interactor 13
VGLL1 vestigial-like family member 1