BRD-U61997977_WZ-4-145_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-U61997977_WZ-4-145_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMACR alpha-methylacyl-CoA racemase
ANXA4 annexin A4
BLVRB biliverdin reductase B
C3 complement component 3
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CD46 CD46 molecule, complement regulatory protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CLU clusterin
CRYZ crystallin, zeta (quinone reductase)
CTSA cathepsin A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GRN granulin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
KRT5 keratin 5, type II
KYNU kynureninase
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
LGALS3 lectin, galactoside-binding, soluble, 3
MAGED2 melanoma antigen family D2
MEIS1 Meis homeobox 1
MPPED2 metallophosphoesterase domain containing 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PEG3 paternally expressed 3
PLD3 phospholipase D family, member 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
QPRT quinolinate phosphoribosyltransferase
RBM47 RNA binding motif protein 47
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPATA20 spermatogenesis associated 20
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SQLE squalene epoxidase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
TTC39A tetratricopeptide repeat domain 39A
TUG1 taurine up-regulated 1 (non-protein coding)
UBXN4 UBX domain protein 4
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CACYBP calcyclin binding protein
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
IGFBP3 insulin-like growth factor binding protein 3
JUN jun proto-oncogene
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAQR4 progestin and adipoQ receptor family member IV
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMC3IP PSMC3 interacting protein
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SERTAD2 SERTA domain containing 2
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein