BRD-U61997977_WZ-4-145_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-U61997977_WZ-4-145_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP13 A kinase (PRKA) anchor protein 13
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
C14ORF1 chromosome 14 open reading frame 1
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CES2 carboxylesterase 2
CRABP2 cellular retinoic acid binding protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFA5 defensin, alpha 5, Paneth cell-specific
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EGR1 early growth response 1
FABP1 fatty acid binding protein 1, liver
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GRN granulin
GSE1 Gse1 coiled-coil protein
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
KDM5B lysine (K)-specific demethylase 5B
KIAA0226L KIAA0226-like
KIF5C kinesin family member 5C
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LXN latexin
MAB21L1 mab-21-like 1 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEIS1 Meis homeobox 1
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHYH phytanoyl-CoA 2-hydroxylase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRUNE2 prune homolog 2 (Drosophila)
RAB29 RAB29, member RAS oncogene family
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RTN2 reticulon 2
S100A11 S100 calcium binding protein A11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERINC3 serine incorporator 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC22A18 solute carrier family 22, member 18
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TBX2 T-box 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGIF1 TGFB-induced factor homeobox 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANOS1 anosmin 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPT dermatopontin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HMGB1 high mobility group box 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT13 keratin 13, type I
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MCUR1 mitochondrial calcium uniporter regulator 1
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSIP1 PC4 and SFRS1 interacting protein 1
RAD51AP1 RAD51 associated protein 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SSRP1 structure specific recognition protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCF3 transcription factor 3
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)