BRD-U60236422_WH-4-025_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-U60236422_WH-4-025_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ARL4C ADP-ribosylation factor-like 4C
BASP1 brain abundant, membrane attached signal protein 1
CCL5 chemokine (C-C motif) ligand 5
CD2 CD2 molecule
CLIC3 chloride intracellular channel 3
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
FGL2 fibrinogen-like 2
GATA3 GATA binding protein 3
GLS glutaminase
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL32 interleukin 32
KDM3A lysine (K)-specific demethylase 3A
KLHL21 kelch-like family member 21
LAMP3 lysosomal-associated membrane protein 3
MPPED2 metallophosphoesterase domain containing 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PRKCQ protein kinase C, theta
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIK1 salt-inducible kinase 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRR1A small proline-rich protein 1A
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM204 transmembrane protein 204
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TRD T cell receptor delta locus
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
BMP4 bone morphogenetic protein 4
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CD24 CD24 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CLU clusterin
CP ceruloplasmin (ferroxidase)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEFB1 defensin, beta 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAL histidine ammonia-lyase
HES1 hes family bHLH transcription factor 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP1 insulin-like growth factor binding protein 1
JUN jun proto-oncogene
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYRM1 LYR motif containing 1
MAGEA3 melanoma antigen family A3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
OLFM4 olfactomedin 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON2 paraoxonase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
SKAP2 src kinase associated phosphoprotein 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THSD7A thrombospondin, type I, domain containing 7A
TM4SF1 transmembrane 4 L six family member 1