BRD-U51024685_HG-6-64-01_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-U51024685_HG-6-64-01_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP1 aquaporin 1 (Colton blood group)
ASRGL1 asparaginase like 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CP ceruloplasmin (ferroxidase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FGFR1 fibroblast growth factor receptor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HCP5 HLA complex P5 (non-protein coding)
HP haptoglobin
IFRD2 interferon-related developmental regulator 2
LDHB lactate dehydrogenase B
LPAR6 lysophosphatidic acid receptor 6
LRP4 low density lipoprotein receptor-related protein 4
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM5 PDZ and LIM domain 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
SATB2 SATB homeobox 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CALML5 calmodulin-like 5
CCND1 cyclin D1
CD24 CD24 molecule
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FLNA filamin A, alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
MLANA melan-A
NDN necdin, melanoma antigen (MAGE) family member
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PRKCZ protein kinase C, zeta
SCUBE2 signal peptide, CUB domain, EGF-like 2
TFRC transferrin receptor
TSPAN3 tetraspanin 3
TYRP1 tyrosinase-related protein 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)