BRD-U51024685_HG-6-64-01_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
AIF1 allograft inflammatory factor 1
ALDOC aldolase C, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL11A1 collagen, type XI, alpha 1
CST3 cystatin C
CTSB cathepsin B
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP10 dual specificity phosphatase 10
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GABARAP GABA(A) receptor-associated protein
GAS6 growth arrest-specific 6
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GSN gelsolin
H1F0 H1 histone family, member 0
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LCN2 lipocalin 2
LRRC8D leucine rich repeat containing 8 family, member D
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PDZK1 PDZ domain containing 1
PHGDH phosphoglycerate dehydrogenase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PINK1 PTEN induced putative kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STAB1 stabilin 1
STXBP2 syntaxin binding protein 2
TFF3 trefoil factor 3 (intestinal)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TYROBP TYRO protein tyrosine kinase binding protein
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP57 centrosomal protein 57kDa
CHEK2 checkpoint kinase 2
CNN3 calponin 3, acidic
COL6A1 collagen, type VI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HAT1 histone acetyltransferase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0020 KIAA0020
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NES nestin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPAT phosphoribosyl pyrophosphate amidotransferase
PRF1 perforin 1 (pore forming protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SRP72 signal recognition particle 72kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCL1A T-cell leukemia/lymphoma 1A
TDO2 tryptophan 2,3-dioxygenase
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1