BRD-U51024685_HG-6-64-01_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AHNAK2 AHNAK nucleoprotein 2
ANGPTL2 angiopoietin-like 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCND2 cyclin D2
CDC25B cell division cycle 25B
CDK18 cyclin-dependent kinase 18
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
CREB1 cAMP responsive element binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSF1R colony stimulating factor 1 receptor
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DENND1B DENN/MADD domain containing 1B
DEPTOR DEP domain containing MTOR-interacting protein
DPP4 dipeptidyl-peptidase 4
EFNA1 ephrin-A1
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
IDS iduronate 2-sulfatase
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
JADE2 jade family PHD finger 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LDLR low density lipoprotein receptor
LSR lipolysis stimulated lipoprotein receptor
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MBP myelin basic protein
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NMU neuromedin U
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OPTN optineurin
OSMR oncostatin M receptor
PAEP progestagen-associated endometrial protein
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZD2 PDZ domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF144A ring finger protein 144A
RRAGC Ras-related GTP binding C
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SFXN3 sideroflexin 3
SH3YL1 SH3 and SYLF domain containing 1
SHB Src homology 2 domain containing adaptor protein B
SLC22A18 solute carrier family 22, member 18
SLC38A1 solute carrier family 38, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TDO2 tryptophan 2,3-dioxygenase
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UBE2I ubiquitin-conjugating enzyme E2I
VAT1 vesicle amine transport 1
WASF1 WAS protein family, member 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF292 zinc finger protein 292
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALCAM activated leukocyte cell adhesion molecule
ASPH aspartate beta-hydroxylase
BDNF brain-derived neurotrophic factor
CCND1 cyclin D1
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CKAP4 cytoskeleton-associated protein 4
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGF2 fibroblast growth factor 2 (basic)
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GNAS GNAS complex locus
GSTT1 glutathione S-transferase theta 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
JUN jun proto-oncogene
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NAV3 neuron navigator 3
NES nestin
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52L2 tumor protein D52-like 2
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
WDR1 WD repeat domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein