BRD-U51024685_HG-6-64-01_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-U51024685_HG-6-64-01_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADAM28 ADAM metallopeptidase domain 28
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA11 carbonic anhydrase XI
CA12 carbonic anhydrase XII
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COPA coatomer protein complex, subunit alpha
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FZD1 frizzled class receptor 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPATCH8 G patch domain containing 8
IFITM1 interferon induced transmembrane protein 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
LPAR6 lysophosphatidic acid receptor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
NDRG2 NDRG family member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAB39 calcium binding protein 39
CAV1 caveolin 1, caveolae protein, 22kDa
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
COCH cochlin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP3 dual specificity phosphatase 3
EPCAM epithelial cell adhesion molecule
EPHB2 EPH receptor B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JUN jun proto-oncogene
JUP junction plakoglobin
KCNK1 potassium channel, two pore domain subfamily K, member 1
L1CAM L1 cell adhesion molecule
MAGEA3 melanoma antigen family A3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYL9 myosin, light chain 9, regulatory
NRIP1 nuclear receptor interacting protein 1
NUTF2 nuclear transport factor 2
PFKP phosphofructokinase, platelet
PLAU plasminogen activator, urokinase
PLN phospholamban
PRSS3 protease, serine, 3
SAMD4A sterile alpha motif domain containing 4A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SET SET nuclear proto-oncogene
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
TAGLN transgelin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THSD7A thrombospondin, type I, domain containing 7A
TPM1 tropomyosin 1 (alpha)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCL vinculin
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZYX zyxin