BRD-U44618005_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-U44618005_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
CLIC4 chloride intracellular channel 4
COCH cochlin
CTSA cathepsin A
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DUSP4 dual specificity phosphatase 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GPC3 glypican 3
IL17RB interleukin 17 receptor B
IL2RG interleukin 2 receptor, gamma
INSIG1 insulin induced gene 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MOXD1 monooxygenase, DBH-like 1
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
NES nestin
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
ODAM odontogenic, ameloblast asssociated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEBP1 phosphatidylethanolamine binding protein 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PRAME preferentially expressed antigen in melanoma
PTGES prostaglandin E synthase
RAB4A RAB4A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP4 retinol binding protein 4, plasma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL37A ribosomal protein L37a
SCCPDH saccharopine dehydrogenase (putative)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SRPX sushi-repeat containing protein, X-linked
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNM synemin, intermediate filament protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM2 transmembrane protein 2
TNS1 tensin 1
TOX thymocyte selection-associated high mobility group box
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
C6ORF62 chromosome 6 open reading frame 62
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CCND1 cyclin D1
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
ENDOD1 endonuclease domain containing 1
EREG epiregulin
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLIPR1 GLI pathogenesis-related 1
GMPR guanosine monophosphate reductase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAT1 histone acetyltransferase 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
OLFML2A olfactomedin-like 2A
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAWR PRKC, apoptosis, WT1, regulator
PLXNC1 plexin C1
PMM2 phosphomannomutase 2
PON2 paraoxonase 2
PPL periplakin
PRSS23 protease, serine, 23
RANBP1 RAN binding protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
UBE3C ubiquitin protein ligase E3C
VAMP8 vesicle-associated membrane protein 8
VCAN versican
ZKSCAN1 zinc finger with KRAB and SCAN domains 1