BRD-U43867373_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-U43867373_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP8 aquaporin 8
ARMCX1 armadillo repeat containing, X-linked 1
BCL2A1 BCL2-related protein A1
BEX4 brain expressed, X-linked 4
C1ORF115 chromosome 1 open reading frame 115
CA4 carbonic anhydrase IV
CCL5 chemokine (C-C motif) ligand 5
CD177 CD177 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELF2 CUGBP, Elav-like family member 2
CENPU centromere protein U
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DUSP14 dual specificity phosphatase 14
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXO11 F-box protein 11
FGFR2 fibroblast growth factor receptor 2
FZD5 frizzled class receptor 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREB1 growth regulation by estrogen in breast cancer 1
HCAR3 hydroxycarboxylic acid receptor 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
MEIS2 Meis homeobox 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSAD2 radical S-adenosyl methionine domain containing 2
S100A14 S100 calcium binding protein A14
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SESN1 sestrin 1
SOCS1 suppressor of cytokine signaling 1
SPARCL1 SPARC-like 1 (hevin)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STXBP6 syntaxin binding protein 6 (amisyn)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM30B transmembrane protein 30B
TP53BP2 tumor protein p53 binding protein 2
TSKU tsukushi, small leucine rich proteoglycan
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ASCC3 activating signal cointegrator 1 complex subunit 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
BRCA1 breast cancer 1, early onset
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CAPRIN2 caprin family member 2
CCND1 cyclin D1
CCNF cyclin F
CD302 CD302 molecule
CDR2L cerebellar degeneration-related protein 2-like
CEMIP cell migration inducing protein, hyaluronan binding
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPN2 epsin 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FGB fibrinogen beta chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HOPX HOP homeobox
HOXC6 homeobox C6
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP1 insulin-like growth factor binding protein 1
ITGA6 integrin, alpha 6
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LRRC41 leucine rich repeat containing 41
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MALT1 MALT1 paracaspase
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
NNMT nicotinamide N-methyltransferase
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP4 poly(rC) binding protein 4
PCCA propionyl CoA carboxylase, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PREB prolactin regulatory element binding
PRKCA protein kinase C, alpha
PROS1 protein S (alpha)
RECQL RecQ helicase-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPATA20 spermatogenesis associated 20
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX2 sushi-repeat containing protein, X-linked 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC3 trafficking protein particle complex 3
TUBA4A tubulin, alpha 4a
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WSB2 WD repeat and SOCS box containing 2